青年与中老年乳腺癌患者临床病理特征及免疫组化特点对比研究  

The study of clinicopathological and immunohistochemical characteristics in young and middle aged breast cancer

作　　者：姬荣伟 刘芳[2] 田亚宁[2] 田刘曼 王志斌 Ji Rongwei;Liu Fang;Tian Yaning(Department of Pathology,Xi’an XD Group Hospital(Xi’an710077))

机构地区：[1]西电集团医院病理科,西安710077 [2]陕西中医药大学第二附属医院病理科,咸阳712000 [3]西北妇女儿童医院妇五科,西安710061 [4]陕西省核工业二一五医院肿瘤科,咸阳712000

出　　处：《陕西医学杂志》2018年第8期1081-1083,共3页Shaanxi Medical Journal

摘　　要：目的:比较青年与中老年乳腺癌患者临床病理特征及免疫组化特点之间的差异,为临床诊断与治疗提供参考。方法:回顾性分析232例乳腺癌患者的临床资料,根据年龄划分为青年组56例(年龄≤35岁)和中老年组176例(年龄>35岁),比较两组患者肿瘤分期、肿瘤直径、发生部位等临床病理特征和组织学分类、雌激素受体(ER)、孕激素受体(PR)、癌蛋白C-erB-2(C-erbB-2)等免疫组化特征的差异。结果:青年组患者肿瘤分期集中在Ⅱ期(35.71%)和Ⅲ期(48.21%),中老年组患者肿瘤分期集中在Ⅰ期(38.07%)和Ⅱ期(35.80%),比较差异有统计学意义(χ~2=29.648,P<0.01),两组患者肿瘤直径、发生部位比较差异无统计学意义(χ~2=0.091,0.717,P>0.05);青年组乳腺癌患者ER、PR的阳性率明显低于中老年组,C-erbB-2阳性率明显高于中老年组(42.86%与55.68%,41.07%与57.39%,64.29%与44.32%)(χ~2=4.721,5.584,7.769,P<0.05),两组患者乳腺癌组织学分类比较差异无统计学意义(χ~2=0.011,P>0.05)。结论:青年乳腺癌患者临床分期高于中老年组,ER、PR的阳性率较低,C-erbB-2的阳性率较高,且肿瘤侵袭性强,治疗方式受限,预后较差。Objective:To compare the clinicopathological and immunohistochemical characteristics of young and middle aged breast cancer patients and to provide reference for clinical diagnosis and treatment.Methods:The clinical data of 232 cases of breast cancer were retrospectively analyzed.According to their age,they were divided into 56 cases in the youth group(age<35)and 176 cases in the elderly group(age>35);the difference of immunohistochemical characteristics of tumor stages,tumor diameter and site of occurrence,estrogen receptor(ER),progesterone receptor(PR)and C-erbB-2were compared.Results:The stage of tumor in the younger group was in phase II(35.71%)and phase III(48.21%),while the stage of tumor in the elder group was in phase I(38.07%)and phase II(35.80%),with statistical difference(χ2=29.648,P<0.01).The positive rates of ER and PR were significantly lower in the young group than in the elder group,and the positive rates of C-erbB-2 were significantly higher in the older group(42.86%with 55.68%,41.07%with 57.39%,64.29%with 44.32%)(χ2=4.721,5.584,7.769,P<0.05).Conclusion:Young breast cancer patients with clinical s

关 键 词：乳腺肿瘤 年龄 临床病理特征 免疫组化 

分 类 号：R737.9[医药卫生—肿瘤]