补阳回神散配合大剂量纳洛酮治疗急性一氧化碳中毒所致迟发性脑病临床研究  

Clinical study of Buyang Huishen powder combined with large dose of Naloxone in treatment of delayed encephalopathy because of acute carbon monoxide poisoning

作　　者：田爱荣 孙明洁 张晓莉[2] Tian Airong;Sun Mingjie;Zhang Xiaoli(The Traditional Chinese Medicine Department,Henan Workers'Hospital(Zhengzhou 450002))

机构地区：[1]河南省职工医院中医科,郑州450002 [2]新乡医学院第二附属医院精神二科,新乡453002

出　　处：《陕西中医》2018年第8期1018-1021,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：河南省科技厅科技攻关计划项目(0624410035)

摘　　要：目的:观察补阳回神散配合大剂量纳洛酮治疗急性一氧化碳中毒所致迟发性脑病临床疗效。方法:将86例急性一氧化碳中毒所致迟发性脑病患者随机分为两组,对照组43例应用大剂量纳洛酮治疗,研究组43例应用补阳回神散配合大剂量纳洛酮治疗,两组均连续治疗4周。比较两组治疗后临床疗效,记录两组治疗前后简易智能量表(MMSE)评分、Barthel指数评分,统计两组治疗前后血清C反应蛋白(CRP)、白细胞介素-1β(IL-1β)和γ-干扰素(IFN-γ)以及超氧化物歧化酶(SOD)、丙二醛(MDA)水平。结果:研究组治疗后临床治疗总有效率88.37%显著高于对照组67.44%(P<0.05);两组治疗后MMSE评分、Barthel指数评分和血清SOD水平均显著高于治疗前(P<0.05),且研究组MMSE评分、Barthel指数评分和血清SOD水平均显著高于对照组(P<0.05);两组治疗后血清CRP、IL-1β、IFN-γ和MDA水平均显著低于治疗前(P<0.05),且研究组血清CRP、IL-1β、IFN-γ和MDA水平均显著低于对照组(P<0.05)。结论:补阳回神散配合大剂量纳洛酮治疗急性一氧化碳中毒所致迟发性脑病,疗效确切,并且可有效提高患者认知功能和日常生活能力。Objective:To observe the clinical curative effects of Buyang Huishen powder combined with large dose of Naloxone in treatment of delayed encephalopathy because of acute carbon monoxide poisoning.Methods:86 delayed encephalopathy patients because of acute carbon monoxide poisoning were randomly divided into two groups,43 cases in the control group were treated with large dose of Naloxone,43 cases in the study group were treated with Buyang Huishen powder combined with large dose of Naloxone,the two groups were treated continuously for 4 weeks.The clinical efficacy of the two groups after treatment was compared,the Mini-mental State Examination(MMSE)score and the Barthel index score of the two groups before and after treatment were recorded,the levels of serum C reactive protein(CRP),interleukin-1β(IL-1β),interferon-γ(IFN-γ),superoxide dismutase(SOD)and malondialdehyde(MDA)in the two groups before and after treatment were statistically analyzed.Results:After treatment,the total effective rate of clinical treatment in the study group was 88.37%significantly higher than that in the control group 67.44%(P<0.05);the MMSE score,Barthel index score and serum SOD level in the two groups were significantly higher than those before treatment(P<0.05),and the above indexes in the study group were significantly higher than those in the control group(P<0.05);the levels of serum CRP,IL-1β,IFN-γand MDA in the two groups were significantly lower than those before the treatment(P<0.05),and the above indexes in the study group were significantly lower than those in the control group(P<0.05).Conclusion:Buyang Huishen powder combined with large dose of Naloxone in treatment of delayed encephalopathy because of acute carbon monoxide poisoning has a curative effect,and can improve the patients'cognitive function and ability of daily living.

关 键 词：一氧化碳中毒/中西医结合疗法 @迟发性脑病 纳洛酮/治疗应用 

分 类 号：R749.63[医药卫生—神经病学与精神病学]