猕猴脊髓损伤研究长时程麻醉方案的建立及评价  

Establishment and evaluation of a long-term anesthesia protocol for studies of spinal cord injury in macaques

作　　者：马小翠 唐涛 刘少君 MA Xiaocui;TANG Tao;LIU Shaojun(Cancer Hospital of China Medical University;Liaoning Cancer Hospital&Institute,Shenyang 110042,China;Department of Neurobiology,Beijing Institute of Basic Medical Sciences,Beijing 100850)

机构地区：[1]中国医科大学肿瘤医院,辽宁省肿瘤医院,沈阳110042 [2]军事科学院军事医学研究院基础医学研究所神经生物学教研室,北京100850

出　　处：《中国比较医学杂志》2018年第7期87-91,共5页Chinese Journal of Comparative Medicine

摘　　要：目的为成功构建猕猴脊髓损伤模型及其它猕猴长时程手术操作提供一种简单易行的麻醉方案。方法选取雄性成年猕猴10只,采用丙泊酚静脉诱导、异氟醚吸入维持的复合麻醉方式进行麻醉,记录麻醉诱导时间、麻醉维持时间以及麻醉苏醒时间。持续监测血氧饱和度(SpO_2)、呼吸频率(RR)、心率(HR),并通过对其分析评价麻醉方案的可行性及有效性。结果 10只猕猴均按实验计划完成实验,麻醉诱导时间短、起效快,麻醉期间生命体征平稳,镇静、镇痛及肌松满意,术后苏醒迅速、完全,未发生麻醉并发症。结论丙泊酚与异氟醚复合麻醉方式是一种安全有效的猕猴长时程麻醉方案。Objective To provide a simple,convenient,and safe anesthesia method for long-term operations in macaques.Methods Ten male Macaca mulatta macaques were anesthetized by a combination of intravenous anesthesia with propofol and isoflurane inhalation.The induction time,duration of anesthesia,and recovery time were recorded.After continuous monitoring of blood oxygen saturation,respiratory rate,and heart rate,the feasibility and effectiveness of the anesthetic scheme was evaluated by data analysis.Results All 10 monkeys survived the experimental anesthesia protocol.The anesthesia induction time was short and the onset was rapid.During anesthesia,vital signs were stable,and the sedation,analgesia,and muscle relaxation were satisfactory.Conclusions Combined anesthesia induced by propofol and isoflurane is a safe and effective method for long-term anesthesia of macaques.

关 键 词：猕猴 麻醉 丙泊酚 异氟醚 

分 类 号：R-33[医药卫生]