酸性调宁蛋白的研究进展  

Research progress of acid calponin

作　　者：雷蕾[1] 刀庆 牛成慧 韩雁冰[1] LEI Lei;DAO Qing;NIU Chenghui;HAN Yanbing(Department of Neurology,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)

机构地区：[1]昆明医科大学第一附属医院神经内科,昆明650032

出　　处：《中国比较医学杂志》2018年第7期92-96,共5页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金资助项目(编号:81660228);云南省科技计划项目(编号:2017FA041);云南省教育厅科学研究基金研究生项目(编号:2016YJS055)

摘　　要：酸性调宁蛋白是一种肌动蛋白结合蛋白,它在平滑肌细胞和非肌细胞中均有表达,并且参与树突棘重塑、细胞骨架重组、平滑肌细胞收缩调控、骨骼肌发育调节、胎盘形成与胚胎发育、细胞的信号传导等。酸性调宁蛋白表达的改变与耐药性癫痫、大肠癌、黏膜相关淋巴组织淋巴瘤、卵巢癌的发生进展相关,研究该蛋白表达量的改变有利于这些疾病的诊断及预后的判断。Acid calponin is an actin filament-associated regulatory protein expressed in smooth muscle and non-muscle cells.The roles of acid calponin in regulating dendritic spine remodeling,cytoskeletal rearrangement,smooth muscle contraction,skeletal muscle development,placentation processes,embryonic development,and signal transduction have been investigated extensively.These roles indicate that changes in acid calponin expression are related to the occurrence and development of drug-resistant epilepsy,colorectal cancer,mucosa-associated lymphoid tissue lymphoma,and ovarian cancer,which are significant for diagnosis and prognosis.

关 键 词：调宁蛋白 树突棘重塑 细胞骨架重组 平滑肌 

分 类 号：R-33[医药卫生]