灵长类巨细胞病毒慢性潜伏再激活诱导免疫衰老的研究进展  

Research progress on chronic latent reactivation of primate cytomegalovirus-induced immune senescence

作　　者：王宇虹[1,2] 曲光瑾 肖冲[3] 邓巍 WANG Yuhong;QU Guangjin;XIAO Chong;DENG Wei(Department of Geriatric,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China;National Clinical Research Center for Geriatric Disease,Chinese PLA General Hospital,Beijing 100039;Institute of Laboratory Animal Sciences,Chinese Academy of Medical Sciences(CAMS);Comparative Medicine Center,Peking Union Medical College(PUMC),Beijing 100021)

机构地区：[1]哈尔滨医科大学附属第一医院干部病房,哈尔滨150001 [2]解放军总医院国家老年疾病临床医学研究中心,北京100039 [3]中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,北京100021

出　　处：《中国比较医学杂志》2018年第7期124-128,共5页Chinese Journal of Comparative Medicine

摘　　要：巨细胞病毒(cytomegalovirus,CMV)免疫潜伏再激活可以诱导T细胞进而发生免疫衰老已成为衰老的公认机制之一。在免疫活性宿主体内,CMV一旦感染可在骨髓中静默潜伏,通过分化依赖性活化刺激进入循环传播,保持终生持续感染的能力。本文针对人类和非人灵长类CMV感染后免疫状况、免疫逃避机制以及与免疫衰老相关性等方面进行比较和综述,以期为今后免疫衰老模型构筑、疫苗研制和药物开发提供基础。Reactivation of cytomegalovirus(CMV)can induce T cells to undergo immune senescence,a mechanism of aging.After CMV infection of immunocompetent hosts,it persists in bone marrow.CMV is stimulated and propagates into circulation via differentiation-dependent reactivation throughout life.This article compares and reviews the immune status of human and nonhuman primates after CMV infection,the immune escape mechanisms,and the relationship with immune senescence.Such information may provide a basis for establishing models of immune senescence and the development of drugs and vaccines.

关 键 词：巨细胞病毒 免疫衰老 比较医学 灵长类 

分 类 号：R-33[医药卫生]