小牛血清去蛋白注射液联合依达拉奉治疗急性大面积脑梗死的临床观察  

Clinical Observation of Deproteinised Calf Blood Injecion Capsules Combined with Edaravone in the Treatment of Acute Cerebral Infarction

作　　者：傅驰 李作孝 FU Chi;LI Zuo-xiao(The Affiliated Hospital of Southwest Medical,Luzhou Sichuan 646000)

机构地区：[1]西南医科大学附属医院,四川泸州646000

出　　处：《世界最新医学信息文摘》2018年第18期27-29,共3页World Latest Medicine Information Electronic Version

摘　　要：目的探讨小牛血清去蛋白注射液联合依达拉奉治疗急性大面积脑梗死的临床疗效及安全性。方法选取2015年7月至2017年1月于我院住院治疗的急性大面积脑梗死患者156例,采用随机数字表法随机分为实验组(78例)和对照组(78例)。实验组在常规治疗基础上给予依达拉奉注射液30mg加入100m L0.9%氯化钠溶液中静脉滴注,每日两次,30分钟内滴完,小牛血清去蛋白注射液0.8g加入100m L0.9%氯化钠溶液中静脉滴注,每日一次;对照组在相同常规治疗基础上仅给予依达拉奉注射液30mg加入100m L0.9%氯化钠溶液中静脉滴注,每日两次,30分钟内滴完,均给予2周的治疗时间。比较两组患者一般资料及治疗前后的血纤维蛋白原(Fibrinogebn,FIB)、D-二聚体(D-dimer)、白细胞介素6(Interleukin,IL-6)、P选择素(P-selectin,CD62P)、超敏C反应蛋白(Hypersensitive C-reactive protein,h S-CRP)、改良Rankin量表(Modified Rankin Scale,m RS)评分、神经功能缺损程度评分(National Institute of Health Stroke Scale,NIHSS评分)、有效率及不良反应情况。结果治疗前两组患者在年龄、性别、病史及血生化指标等方面无明显差异(P>0.05);治疗后两组患者FIB、D-二聚体、IL-6、CD62P、h S-CRP、m RS评分、NIHSS评分较治疗前均下降,差异有统计学意义(P<0.05),且与对照组比较实验组下降更为明显(P<0.05);实验组总有效率显著高于对照组,差异有统计学意义(P<0.05);治疗期间两组均未见明显不良反应。结论急性大面积脑梗死在常规基础治疗上,加用小牛血清去蛋白注射液联合依达拉奉注射液可通过影响P选择素、D-二聚体、FIB等来改善血小板聚集状态以及减轻炎症反应途径促进患者神经缺损功能恢复,且无明显不良反应。Objective To Observation Clincal efficacy and safety of edaravone and Deproteinised Calf Blood in the treatment of acute large area cerebral infarction.Methods Selected in July 2015 to January 2017 in our hospital hospital treatment of 156 cases of patients with acute large area cerebral infarction,the random number table method were randomLy divided into experimental group(78 cases)and control group(78 cases).Control group was additionally given edaravone injection 30mg+0.9%sodium chloride injection 100mL,ivgtt,bid,drip off within 30 minutes,on the basis of routine treatment.Experimental group was additionally given Deproteinised Calf Blood injection 0.8g+0.9%sodium chloride injection 100mL,ivgtt,qd,on the basis of control group.both groups were treated for two weeks.Clinical efficacies of 2 groups were observed as well as FIB、D-dimer、CD62p、IL-6、hs-CRP、NIHSS score、mRS score and after treatment as well as clinical efficacy before and after treatment,the occurrence of ADR were compared between 2 groups.Results Two groups of patients before treatment in age,gender,history and so on blood biochemical indicators have no obvious difference(P>0.05);In the two groups after treatment FIB,D-dimer,IL-6,CD62P,hS-CRP,mRS score,NIHSS score was decreased,the difference was statistically significant(P<0.05),and compared with the control group decreased more significantly(P<0.05);Group total effective rate was significantly higher than the control group,the difference was statistically significant(P<0.05);There were no obvious adverse reactions during treatment in the two groups.Conclusions Acute massive cerebral infarction on treatment on a regular basis,and calf serum albumen injection adr mentioned joint injection can choose plain by influencing P,D-dimer,FIB,etc to improve the state of platelet aggregation and reduce inflammation reaction to improve the nerve function defect in patients with symptoms,and does not increase obviously adverse reaction.

关 键 词：小牛血清去蛋白注射液 依达拉奉注射液 急性脑梗死 安全性 疗效 

分 类 号：R743.33[医药卫生—神经病学与精神病学]