幽门螺旋杆菌感染与脑小血管病的相关性分析  

Correlation analysis of helicobacter pylori infection and cerebral small vessel disease

作　　者：李雨芹[1] 王思迅[1] 李园园 龙秀英[1] 杨婉 曾倩[1] LI Yuqin;WANG Sixun;LI Yuanyuan;LONG Xiuying;YANG Wan;ZENG Qian(Department of Neurology,the Sixth People’s Hospital of Chengdu,Chengdu 610051,China)

机构地区：[1]成都市第六人民医院神经内科,四川成都610051

出　　处：《中国实用神经疾病杂志》2018年第13期1431-1434,共4页Chinese Journal of Practical Nervous Diseases

基　　金：四川省卫生和计划生育委员会科研课题;编号17PJ093

摘　　要：目的幽门螺旋杆菌感染与脑小血管病的相关性分析。方法选取2017—2018年行头CT或MRI检查的171例患者,诊断为脑小血管142例(脑小血管组),排除脑小血管病的29例患者为对照组,检测幽门螺旋杆菌抗体、血脂等指标,同时通过Logistic回归分析幽门螺旋杆菌等指标是否与脑小血管病相关。结果脑小血管病组与对照组间幽门螺旋杆菌感染比较差异有统计学意义,Logistic回归分析提示幽门螺旋杆菌感染与脑小血管病相关(OR=3.385)。结论幽门螺旋杆菌感染为脑小血管病的危险因素,但仍需进一步验证及研究其机制,从而更好地治疗和预防脑小血管病。Objective To analyze the correlation between Helicobacter pylori infection and cerebral vascular disease.(CSVD).Methods We selected 171 patients who underwent CT or MRI examination form 2017 to 2018,142 patients diagnosed as small cerebral blood vessels,29 patients with small cerebral vascular disease excluded as control group,and tested H.pylori antibody,blood lipids and other indicators.Logistic regression analysis was used to detect whether Helicobacter pylori and other indicators were related to cerebral vascular disease.Results There were significant differences in Helicobacter pylori infection between the cerebral small vessel disease group and the control group.Logistic regression analysis indicated that Helicobacter pylori infection was associated with cerebral small vessel disease(OR=3.385).Conclusion Helicobacter pylori infection is the risk factor of CSVD,we should further verify and study its mechanism,in order to better prevention and treatment of cerebral small vessel disease.

关 键 词：脑小血管病 幽门螺旋杆菌 感染 相关性分析 卒中 认知功能障碍 腔隙性梗死 

分 类 号：R743[医药卫生—神经病学与精神病学]