瓦里安TRUEBEAM直线加速器的临床应用——VMAT技术治疗根治术后前列腺癌患者的效果  

Clinic Application of Varian TRUEBEAM Linear Accelerator——Therapeutic outcome of VMAT of Patients after prostatectomy

作　　者：徐勇刚[1] 李高峰[1] Xu Yonggang;Li Gaofeng(Department of Radiation Oncology,Beijing Hospital,National Center of Gerontology,Beijing 100730,China)

机构地区：[1]北京医院国家老年医学中心放射治疗科,北京100730

出　　处：《医疗装备》2018年第13期101-103,共3页Medical Equipment

摘　　要：目的回顾性分析老年前列腺癌患者根治术后接受瓦里安TRUEBEAM直线加速器容积旋转调强放射治疗(VMAT)的疗效和不良事件。方法选取2014年8月至2017年7月收治的43例接受术后VMAT的前列腺癌患者,全组患者中25例接受辅助放射治疗(ART),18例接受挽救放射治疗(SRT),其中12例接受了盆腔淋巴结区域以及前列腺瘤床区域放射治疗,31例仅接受了前列腺瘤床区域放射治疗,盆腔放射治疗中位剂量为48 Gy,前列腺瘤床区域中位剂量为70 Gy。结果中位随访21个月,全组3年总生存(OS)、无生化失败生存(BRFS)和局部控制(LC)分别为97.6%、85.3%和100.0%。≥3级的直肠不良事件发生率为0.0%,有1例患者膀胱发生3级不良事件,未有患者出现4级膀胱反应。结论前列腺癌患者根治术后采用瓦里安TRUEBEAM直线加速器VMAT技术可以获得显著的疗效,晚期不良事件轻微。Objective To evaluate the clinical outcome and adverse event with volumetric-modulated arc therapy(VMAT)following prostatectomy for elderly patients.Methods 43 prostate cancer patients admitted from August 2014 to July 2017 who received VMAT after surgery were selected.Among these patients,25 received adjuvant radiotherapy(ART)and 18 received salvage radiotherapy(SRT).12 of the patients received radiation treatment in the pelvic lymph node area and the prostate tumor bed area,while 31 received radiation treatment only in the prostate tumor bed area.The median dose of pelvic radiation therapy was 48 Gy,and that of prostate tumor bed was 70 Gy.Results Median follow-up was 21 months.The 3-year overall survival(OS),biochemical relapse-free survival(BRFS)and local control(LC)were 97.6%,85.3%and 100.0%.The incidence rate of rectal adverse event greater than or equal to grade 3 was 0.0%,and 1 patient had grade 3 adverse event in the bladder,while no patient had grade 4 bladder reactions.Conclusion The current results indicated that VMAT following prostatectomy resulted in a high OS,BRFS and LC,and a mild adverse event.

关 键 词：前列腺癌 术后放射治疗 容积旋转调强放射治疗 

分 类 号：R730.5[医药卫生—肿瘤]