吡格列酮治疗非酒精性脂肪肝的疗效分析  

Clinical effect analysis of pioglitazone in the treatment of non-alcoholic fatty liver

作　　者：熊玮[1] 唐淑亚 唐顺利 Xiong Wei;Tang Shuya;Tang Shunli(Infection Department,Guizhou Aerospace Hospital(Zunyi)563000)

机构地区：[1]贵州航天医院感染科,遵义563000

出　　处：《中国社区医师》2018年第22期65-65,67,共2页Chinese Community Doctors

摘　　要：目的:探讨吡格列酮治疗非酒精性脂肪肝(NAFLD)的疗效。方法:收治NAFLD患者78例,分为两组。对照组给予肌苷片、维生素类、还原型谷胱甘肽等药物治疗,治疗组在对照组基础上给予盐酸吡格列酮片治疗,比较两组治疗12、24周的血糖、血脂、肝功能、胰岛素抵抗指数(HOMA-IR)情况。结果:治疗组治疗12、24周后ALT明显低于对照组,差异有统计学意义(P<0.05)。治疗组治疗24周后ALT复常率高于对照组,HOMA-IR、甘油三酯水平低于对照组,差异有统计学意义(P<0.05)。结论:吡格列酮治疗NAFLD有效,能改善患者的胰岛素抵抗。Objective:To explore the clinical effect of pioglitazone in the treatment of non-alcoholic fatty liver.Methods:78 cases of patients with non-alcoholic fatty liver were divided into two groups.The control group was treated with inosine tablets,vitamins,and reduced glutathione,the treatment group was treated with pioglitazone hydrochloride tablets on the basis of the control group,the blood glucose,blood lipid,liver function and insulin resistance index(HOMA-IR)between the two groups after treatment for 12 weeks and 24 weeks were compared.Results:After treatment for 12 weeks and 24 weeks,the ALT of the treatment group was significantly lower than that of the control group,the difference was statistically significant(P<0.05).After treatment for 24 weeks,the rate of recovery in the treatment group was higher than that of the control group,the difference was statistically significant(P<0.05).The level of HOMA-IR and triglyceride in the treatment group were lower than those of the control group after treatment for 24 weeks,and the difference was statistically significant(P<0.05).Conclusion:Pioglitazone was effective in the treatment of non-alcoholic fatty liver and could improve the insulin resistance in patients.

关 键 词：吡格列酮 非酒精性脂肪肝 胰岛素抵抗 

分 类 号：R575.5[医药卫生—消化系统]