唾液幽门螺杆菌检测在胃癌发生发展中的价值  

The value of the Helicobacter pylori in saliva in the occurrence and development of gastric cancer

作　　者：罗伟 朱志超 徐宝宏[1] 罗振华 LUO Wei;ZHU Zhichao;XU Baohong;LUO Zhenhua(Department of Gastroenterology,Beijing Luhe Hospital,Capital Medical University,Beijing 101101,China;Department of Periodontics,Beijing Stomatological Hospital,Capital Medical University,Beijing 101101,China)

机构地区：[1]首都医科大学附属北京潞河医院消化内科,北京101101 [2]首都医科大学附属北京口腔医院牙周科,北京101101

出　　处：《中国医药导报》2018年第22期88-91,共4页China Medical Herald

摘　　要：目的研究唾液幽门螺杆菌(Hp)与胃癌发展各阶段的相关性。方法选取2016年1月~2017年10月首都医科大学附属北京潞河医院201例病理诊断为浅表性胃炎、萎缩性胃炎、不典型增生及胃癌的患者唾液,应用幽门螺杆菌唾液检测板(HPS)检测法对唾液Hp进行检测,同时根据年龄、性别、牙周状况及胃内不同病变分组,分析口腔Hp感染率及其相关性。结果纳入试验的患者中,男性Hp感染率(75.5%)高于女性(54.5%),差异有统计学意义(P<0.05);青年组Hp感染率为42.9%,中年组为69.9%,老年组为75.4%,三组间比较差异有统计学意义(P<0.05);萎缩性胃炎组、不典型增生组、胃癌组口腔Hp感染率分别为64.5%、76.0%、75.0%,明显高于浅表性胃炎组(44.4%),差异均有统计学意义(P<0.05);牙龈炎组、牙周炎组患者的口腔Hp感染率与牙周健康组比较明显增高,差异均有统计学意义(P<0.05);牙周炎组与牙龈炎组Hp感染率比较明显增高,差异有统计学意义(P<0.05)。结论幽门螺杆菌在口腔中存在高感染率现象,口腔幽门螺杆菌感染率与年龄、性别因素及牙周炎有关。口腔Hp感染率与胃癌前病变和胃癌的病变有关,可能是胃癌前病变和胃癌的重要危险因素。Objective To investigate the correlation between salivary Helicobacter pylori(Hp)and various stages of gastric cancer development.Methods Saliva was collected from 201 patients with pathologically diagnosed superficial gastritis,atrophic gastritis,dysplasia,and gastric cancer in Beijing Luhe Hospital,Capital Medical University from January 2016 to October 2017.The HPS test was used to detect Hp in saliva.The incidence and correlation of Hp infection were analyzed according to age,sex,periodontal status,and different gastric lesions.Results Among all patients included in the trial,the male infection rate(75.5%)was higher than that of female(54.5%)(P<0.05).The Hp infection rates of middle-aged and elderly patients were 69.9%and 75.4%respectively,which were significantly different from the younger ones(42.9%)(P<0.05).The positive rates of oral Hp in the atrophic gastritis group,atypical hyperplasia group,and gastric cancer group were 64.5%,76.0%,and 75.0%,respectively,which were significantly higher than superficial gastritis group(44.4%),and the differences were statistically significant(P<0.05).The infection rates of gingivitis group and periodontitis group were higher than periodontal health group,and the differences were statistically significant(P<0.05).Conclusion Oral Hp infection rate is higher in the oral cavity,and related to age,gender and periodontal disease.The oral Hp infection rate is related to the precancerous lesions and gastric cancer.The presence of oral Hp may be an important risk factor for gastric precancerous lesions and gastric cancer.

关 键 词：幽门螺杆菌 唾液 胃癌前病变 胃癌 牙周炎 

分 类 号：R735.2[医药卫生—肿瘤]