鱼藤素对胃癌细胞SGC7901/VCR细胞活力的影响研究  

Effect of Deguelin on Cell Viability of Gastric Cancer Cell Line SGC7901/VCR

作　　者：陈立加[1] 张双喜[1] 黄景彬[1] 高卓维[1] CHEN Li-jia;ZHANG Shuang-xi;HUANG Jing-bin;GAO Zhuo-wei(Shunde Hospital of Guangzhou University of Traditional Chinese Medicine,Foshan 528300,China)

机构地区：[1]广州中医药大学顺德医院,广东佛山528300

出　　处：《中国医药指南》2018年第19期36-37,共2页Guide of China Medicine

基　　金：广东省中医药局(项目编号:20152105)

摘　　要：目的研讨鱼藤素对胃癌多药耐药细胞活力的影响。方法应用CCK-8法测定鱼藤素对胃癌细胞SGC7901/VCR活力的变化。结果CCK-8法检测结果显示:鱼藤素在不同浓度(100、250、500μg/mL)对胃癌细胞SGC7901/VCR活力有不同程度的抑制作用,并呈现出浓度和时间梯度依赖性,当药物终浓度为250μg/mL作用时间为12、24 h时,对胃癌细胞SGC7901/VCR的抑制率分别为36.70%、41.10%。结论鱼藤素可能是对抗胃癌多药耐药的一种潜在药物,值得深入研究。Objective To investigate the effect of deguelin on the viability of multidrug resistance in gastric cancer.Methods The changes of SGC7901/VCR activity were measured by CCK-8 method.Results The results of CCK-8 showed that the activity of SGC7901/VCR in different concentrations(100,250,500μg/mL)had different inhibitory effects on the activity of SGC7901/VCR and showed concentration and time gradient The inhibitory rates of SGC7901/VCR were 36.70%and 41.10%,respectively,when the drug concentration was 250μg/mL for 12 and 24 hours.Conclusion Tritosporin may be a potential drug against multidrug resistance of gastric cancer and deserves further study.

关 键 词：胃癌 多药耐药 单体 

分 类 号：R735.2[医药卫生—肿瘤]