移植人脐带干细胞改善乙型肝炎失代偿肝硬化患者的肝功能（英文）  

Transfusion with human umbilical cord mesenchymal stem cells improves liver function in hepatitis B patients with decompensated liver cirrhosis

作　　者：傅青春 金银鹏 王晓今 李莉 王皙 李洪超 汪照静 周丰 臧祖胜 施莉琴 李震宇 陈成伟 Fu Qing-chun;Jin Yin-peng;Wang Xiao-jin;Li Li;Wang Xi;Li Hong-chao;Wang Zhao-jing;Zhou Feng;Zang Zu-sheng;Shi Li-qin;Li Zhen-yu;Chen Cheng-wei(Shanghai Liver Disease Research Center,Nanjing Military Command,Shanghai 200235,China;Shanghai Public Health Clinical Center,Fudan University,Shanghai 201508,China;Shenzhen Beike Cell Engineering Research Institute,Shenzhen 518040,Guangdong Province,China)

机构地区：[1]解放军南京军区上海肝病研究中心,上海市200235 [2]复旦大学附属上海市公共卫生临床中心,上海市201508 [3]深圳北科细胞工程研究所,广东省深圳市518040

出　　处：《中国组织工程研究》2018年第25期3993-4000,共8页Chinese Journal of Tissue Engineering Research

基　　金：the Medical Innovation Project of Nanjing Military Command,No.10MA001~~

摘　　要：背景:失代偿肝硬化是危机生命的慢性肝疾病并发症,是肝移植的主要指标之一。目的:探索人脐带间充质干细胞治疗乙肝肝硬化失代偿患者的安全性和有效性。方法:间充质干细胞治疗组包括17例乙肝肝硬化失代偿患者及对照组包含17例匹配的乙肝失代偿患者。所有患者接受标准乙肝肝硬化治疗,包括口服抗病毒核酸类似物。间充质干细胞治疗组接受肘静脉注射人脐带间充质干细胞。结果与结论:间充质干细胞移植患者肝功能有所改善,白蛋白、胆红素、乳酸脱氢酶及碱性磷酸酶水平有所恢复,且患者Child-Pugh及MELD评分明显恢复。表明人脐带间充质干细胞静脉注射入乙肝肝硬化失代偿患者体内可改善肝功能。BACKGROUND:Decompensated liver cirrhosis,a life-threatening complication of chronic liver disease,is one of the major indications for liver transplantation.OBJECTIVE:To evaluate the safety and efficacy of human umbilical cord mesenchymal stem cell(hUC-MSC)transplantation in hepatitis B patients as a treatment for decompensated liver cirrhosis.METHODS:The mesenchymal stem cell(MSC)treatment group contained 17 hepatitis B patients with decompensated liver cirrhosis and the control group contained 17 matched controls.All patients received conventional treatment for hepatitis B cirrhosis,including the oral administration of antiviral nucleoside analogues.Patients in the MSC treatment group received hUC-MSC infusions into the elbow vein,while control patients received no injection.Follow-up examinations were conducted after treatment to evaluate clinical symptoms,liver function and blood coagulation function.In addition,the severity of cirrhosis was assessed based on the Child-Pugh and Model for End-Stage Liver Disease scores.RESULTS AND CONCLUSION:In this study,we revealed that hUC-MSC-treated patients had an improvement in liver function,as indicated by the recovered albumin,bilirubin,lactate dehydrogenase and alkaline phosphatase levels to some extent.Additionally,hUC-MSC-treated patients had better Child-Pugh and Model for End Stage Liver Disease scores than control patients.Therefore,our findings reveal that the transfusion with hUC-MSCs improves the liver function,which represents a safe approach for treating decompensated liver cirrhosis in hepatitis B patients.

关 键 词：失代偿肝硬化 人脐带间充质干细胞 移植 肝功能 安全性 乙肝肝硬化 标准治疗 干细胞 肝硬化 脐带 组织工程 

分 类 号：R394.2[医药卫生—医学遗传学]