非酒精性脂肪性肝病与人体成分及血脂的相关性  

Relationship between non-alcoholic fatty liver disease and body composition and blood lipid

作　　者：贾德梅[1] 杨莹[2] 王嫱[1] 冯群[1] 顾云帆[1] Jia Demei;Yang Ying;Wang Qiang;Feng Qun;Gu Yunfan(Cadre's Physical Examination Center of Yunnan,Second People's Hospital of Yunnan Province,Kunming650021,China;Department of Endocrinology and Metabolism,Second People's Hospital of Yunnan Province,Kunming650021,China)

机构地区：[1]云南省第二人民医院,云南省干部体检中心,昆明650021 [2]云南省第二人民医院,内分泌代谢科,昆明650021

出　　处：《解剖学杂志》2018年第4期457-460,共4页Chinese Journal of Anatomy

摘　　要：目的:探讨非酒精性脂肪性肝病(NAFLD)与人体成分及血脂指标的相关关系,并分析NAFLD的影响因素,为干预和采取有效NAFLD控制措施提供理论依据。方法:采用基于健康查体人群为基础的回顾性临床病例-对照研究的方法,研究对象为2014年1~8月本院符合条件随机抽取的汉族健康体检者,由279名NAFLD患者和298名体检健康者(对照组)组成,每位对象的人体成分和血脂数据均被完整收集记录,人体成分数据包括总水分、蛋白质、无机盐、体质指数(BMI)、体脂肪率(BFP)、腰围(WC)、腰臀比(WHR)、内脏脂肪面积(VFA)等。所得数据经SPSS 17.0统计软件包进行统计学处理。结果:NAFLD组VFA、WHR水平高于对照组,但是高密度脂蛋白胆固醇(HDL-C)水平低于对照组,差异有统计学意义,而总水分%、蛋白质%、无机盐%、BMI、BFP、WC水平差异均无统计学意义。单因素及多因素非条件Logistic回归分析显示,VFA水平是NAFLD危险因素。结论:NAFLD患者的人体成分及血脂水平与健康人相比存在差异;VFA水平是NAFLD发生的独立危险因素,NAFLD的发生与腹型肥胖存在一定的关系。Objective:To explore the relationship between non-alcoholic fatty liver disease(NAFLD)and body composition and blood lipid,and analyze the related factors of NAFLD so as to provide the scientific basis for its prevention and treatment in future.Methods:Present retrospective study was used in this research.Completed data on body composition and blood lipids of 279 Han nationality cases of NAFLD patients and 298 Han nationality cases of healthy control subjects who took physical examination during January to August in 2014 were collected.The body composition included total body water,protein and mineral,body mass index(BMI),body fat percentage(BFP),waist circumference(WC),waist to hip ratio(WHR),and visceral fat area(VFA)etc.All the results were input into the SPSS 17.0 statistical package.Result:The level of VFA and WHR in the NAFLD patients group were higher than that in the healthy control subjects group,but the level of high density lipoprotein-cholesterol(HDL-C)was lower than the healthy control subjects group and the others had no statistically significant difference.Single factor and multiple factors unconditioned logistic regression analysis showed that the level of VFA was a risk factor of NAFLD.Conclusion:Compared with healthy individuals,the NAFLD patients have significant changes in the level of body composition and blood lipids.VFA is an independent risk factor for NAFLD.NAFLD may be related to abdominal obesity.

关 键 词：非酒精性脂肪肝病 生物电阻抗 人体成分 血脂 

分 类 号：R575.5[医药卫生—消化系统]