β-淀粉样蛋白的分析检测方法研究进展  

Advances in Detection Methods of β-Amyloid Protein

作　　者：蒋萌 王晓英[1] 王小兵 JIANG Meng;WANG Xiao-Ying;WANG Xiao-Bing(Key Laboratory of Environmental Medicine Engineering,Ministry of Education,School of Public Health,Southeast University,Nanjing 210009,China;Department of Natural Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China)

机构地区：[1]环境医学工程教育部重点实验室,东南大学公共卫生学院,南京210009 [2]天然药化教研室,中国药科大学中药学院,南京210009

出　　处：《分析化学》2018年第9期1339-1349,共11页Chinese Journal of Analytical Chemistry

基　　金：本文系国家自然科学基金项目(Nos.81573313,81302472)和江苏省高校“青蓝工程”资助。

摘　　要：阿尔兹海默症(AD)是一种神经退行性疾病,发病机制目前尚不明确。β-淀粉样蛋白(Aβ)是AD的特异性生物标志物之一,众多临床研究提示血液、脑脊液和脑组织内的Aβ水平异常与AD的病程进展密切相关。Aβ的分析评估对AD早期发现、跟踪、预防和治疗具有重要意义。本文就目前国内外Aβ的常用检测方法进行了概述和比较,重点阐述新型电化学生物传感方法在检测Aβ方面的相关应用及其最新研究进展,并对Aβ电化学传感技术的未来发展提出展望。Alzheimer′s disease(AD)is a neurodegenerative disease with unknown etiology.Beta-amyloid protein(Aβ)is one of the specific biomarkers of AD,and many clinical studies suggest that abnormal levels of Aβin blood,cerebrospinal fluid and brain tissue are closely related to the progression of AD.The analysis and evaluation of Aβis important for early detection,tracking,prevention and treatment of AD.In this paper,the present situation of the commonly used detection methods of Aβat home and abroad was summarized and compared.Specifically,the latest application of new electrochemical biosensor in Aβdetection was mainly described,and the summary of its future directions and the potential applications was given.It is intended to provide reference for the further research and application of Aβ.

关 键 词：阿尔兹海默症 Β-淀粉样蛋白 检测方法 电化学生物传感器 评述 

分 类 号：O657.1[理学—分析化学] R749.16[理学—化学] R446.1[医药卫生—神经病学与精神病学]