急性脑梗死患者血清MMP-9、TNF-α、hs-CRP、IL-1β、IL-17水平与颈动脉粥样硬化斑块类型的关系  

Relationship between serum levels of MMP-9, TNF-α, hs-CRP, IL-1β, IL-17 and carotid atherosclerotic plaque in patients with acute cerebral infarction

作　　者：何金邦 赵晓萍 赵秀欣[3] 杨淋 He Jinbang;Zhao Xiaoping;Zhao Xiuxin;Yang Lin(North South Yanchangbu Limited Hospital of Hebei,Tangshan 063305,China)

机构地区：[1]河北南堡盐场有限公司医院,唐山063305 [2]解放军陆军总医院 [3]北京回龙观医院

出　　处：《脑与神经疾病杂志》2018年第9期539-543,共5页Journal of Brain and Nervous Diseases

摘　　要：目的探讨急性脑梗死(ACI)患者血清基质金属蛋白酶9(MMP-9)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、白介素-1β(IL-1β)、白介素-17(IL-17)水平与颈动脉粥样硬化(CAS)斑块类型的关系。方法选取本院收治的52例ACI患者作为研究组,另选取同期在本院进行健康体检的50例健康者作为对照组,检测两组的颈动脉内膜中层厚度(IMT),确定CAS斑块类型。同时采集静脉血进行MMP-9、TNF-α、hs-CRP、IL-1β、IL-17水平检测。结果研究组急性期、恢复期的MMP-9、TNF-α、IL-17、IL-1β、hs-CRP水平均显著高于对照组(P<0.05);研究组恢复期的MMP-9、TNF-α、IL-17、IL-1β、hs-CRP水平均显著低于急性期(P<0.05)。在脑梗死急性期与恢复期,小梗死灶组、中梗死灶组、大梗死灶组的各项炎性因子水平比较差异均有统计学意义,无斑块组、稳定性斑块组、不稳定性斑块组的各项炎性因子水平比较也存在显著性差异(P<0.05),大梗死灶组的MMP-9、TNF-α、IL-17、IL-1β、hs-CRP水平最高,小梗死灶组最低;不稳定性斑块组的MMP-9、TNF-α、IL-17、IL-1β、hs-CRP水平最高,无斑块组最低。结论 ACI患者的血清MMP-9、TNF-α、hs-CRP、IL-1β、IL-17水平与CAS斑块性质有着密切联系,斑块稳定性越差,血清MMP-9、TNF-α、hs-CRP、IL-1β、IL-17水平越高。Objective To investigate the relationship between serum levels of matrix metalloproteinase-9(MMP-9),tumor necrosis factor-α(TNF-α),high sensitive C-reactive protein(hs-CRP),interleukin-1β(IL-1β),interleukin-17(IL-17)and carotid atherosclerotic(CAS)plaque in patients with acute cerebral infarction(ACI).Method Selected 52 patients with ACI as study group,and 50 healthy people who took physical examination as control group.Then determined the carotid intima-media thickness(IMT)level to determine the nature of CAS plaques.At the same time,collected venous blood to detecte the MMP-9,TNF-α,hs-CRP,IL-1βand IL-17 levels.Results The levels of MMP-9,TNF-α,IL-17,IL-1βand hs-CRP in the study group during acute phase and recovery period were significantly higher than control group(P<0.05).The levels of MMP-9,TNF-α,IL-17,IL-1βand hs-CRP in study group during recovery period were significantly lower than those in acute phase(P<0.05).In the acute and recovery stages of cerebral infarction,there were significant differences in the levels of inflammatory cytokines between the small infarction group,the middle infarction group and the large infarction group.And there were also significant differences in the levels of inflammatory cytokines in the non-plaque group,the stable plaque group and the unstable plaque group(P<0.05).The levels of MMP-9,TNF-α,IL-17,IL-1βand hs-CRP in the large infarct group were the highest,while those in the small infarct group were the lowest.The levels of MMP-9,TNF-α,IL-17,IL-1βand hs-CRP in the unstable plaque group were the highest,and the lowest in the plaque group.Conclusion Serum levels of MMP-9,TNF-α,hs-CRP,IL-1βand IL-17 of ACI patients are closely related to the nature of CAS plaques.The worse the plaque stability,the higher the level of serum MMP-9,TNF-α,hs-CRP,IL-1βand IL-17.

关 键 词：颈动脉粥样硬化 斑块性质 脑梗死 炎性因子 

分 类 号：R743.32[医药卫生—神经病学与精神病学]