苏州地区5a早产儿视网膜病变发病率变化趋势分析  

Incidence of retinopathy of prematurity in Suzhou during 5a

作　　者：顾文婷 彭铎[1] 王珍[1] Wen-Ting Gu;Duo Peng;Zhen Wang(Department of Ophthalmology,Suzhou Municipal Hospital,Suzhou 215002,Jiangsu Province,China)

机构地区：[1]中国江苏省苏州市立医院本部眼科,215002

出　　处：《国际眼科杂志》2018年第9期1719-1722,共4页International Eye Science

摘　　要：目的:观察2011/2015年苏州地区早产儿视网膜病变(retinopathy of prematurity,ROP)发病情况。方法:对2011-01/2015-12苏州市立医院本部(苏州市母子中心)NICU收治及ROP专科门诊就诊,并符合筛查标准的2 527例早产、低体质量、有吸氧史的患儿进行ROP筛查。首次检查在出生后4～6wk。接受筛查的2527例患儿,出生体质量640～4200(平均1694.99±370.875)g。出生孕周24.5～41.1(平均32.397±2.2171)wk。采用RetCamⅡ进行眼底检查。按照国际ROP分类法和ROP早期治疗研究标准记录检查结果。双眼病变不对称时,记录病变严重眼;所有接受治疗的病例(阈值前Ⅰ型病变和阈值病变)统一定义为重症ROP。回顾分析近5a间ROP发病率变化及季节分布情况。结果:早产儿2527例中,共发生408例ROP,发病率为16.15%;其中重症ROP 30例,占筛查人数的1.19%。2011/2015年的ROP年发病率分别为10.14%、14.91%、14.26%、19.64%、20.15%,呈逐渐增长趋势(χ~2=24.625,P<0.01),重症ROP为1.18%、0.94%、0.63%、0.90%、2.22%,差异无明显统计学意义(P>0.05)。春夏秋冬四季的ROP发病率分别为17.62%、15.20%、16.12%、15.82%,差异无统计学意义(χ~2=1.397,P=0.706)。结论:苏州地区2011/2015年ROP发病率呈逐渐增长趋势,与出生孕周及出生体质量逐渐减少相关。·AIM:To analyze incidence and trends of retinopathy of prematurity(ROP)from 2011 to 2015 in Suzhou.·METHODS:A total of 2 527 infants were screened for ROP in Suzhou from January 2011 to December 2015 using RetCamII.First examination was performed from 4-6wk after birth.Of all the 2 527 infants,the birth weight was 640-4200g with an average of 1694.99±370.875g.The gestational age were 24.5-41.1wk with an average of 32.397±2.2171wk.The ocular findings were recorded according to the International Classification of ROP and The Early Treatment for ROP.Only the more aggressive eye of bilateral asymmetrical cases was counted for statistical purpose.And the cases required surgeries(pre-threshold ROP typeⅠand threshold ROP)were defined as severe cases.·RESULTS:Of all the 2527 infants,408 infants were screened with ROP,in which 30 were severe ROP,the incidence of ROP and severe ROP was 16.15%and 1.19%.The incidence of ROP from 2011 to 2015 were 10.14%,14.91%,14.26%,19.64%,20.15%respectively,turned out a gradual upward trend(X^2=24.625,P<0.01).The incidence of severe ROP were 1.18%,0.94%,0.63%,0.90%,2.22%,no significant differences between the groups(P>0.05).The incidence of ROP in the four seasons were 17.62%,15.20%,16.12%,15.82%respectively and no significant differences between the groups(X^2=1.397,P=0.706).·CONCLUSION:The incidence of ROP in Suzhou increased from 2011 to 2015,which was related to the decline of the gestational age and birth weight.The distribution of ROP was not seasonal.

关 键 词：早产儿视网膜病变 流行病学 病因学 诊断 新生儿筛查 

分 类 号：R774.1[医药卫生—眼科]