Histopathological findings in cholecystectomies specimens:A single institution study of 20 584 cases  

作　　者：Slim Charfi Naourez Gouiaa Hela Mnif Lassaad Chtourou Nabil Tahri Bassem Abid Rafik Mzali Tahya Sellami Boudawara 

机构地区：[1]Department of Pathology,CHU Habib Bourguiba [2]Sfax Medical School,University of Sfax [3]Department of Gastroenterology,CHU Habib Bourguiba [4]Department of Surgery,CHU Habib Bourguiba

出　　处：《Hepatobiliary & Pancreatic Diseases International》2018年第4期345-348,共4页国际肝胆胰疾病杂志（英文版）

摘　　要：Background: The histopathological examination of cholecystectomy specimens has not been standardized with a debate concerning the routine and the selective approach. The aim of this study was to assess the information obtained from routine histopathological examination of cholecystectomy specimens.Methods: All histopathological reports of cholecystectomy specimens between January 2003 and December 2016 were analyzed, including a clinical diagnosis of benign gallstone disease or cholecystitis.Results: A total of 20,584 reports were examined. The mean age of patients was 54.2 years. Patients aged more than 60 years represent 37.6% of the study population. Of all patients, 15,973(77.6%) were females.Incidental gallbladder cancers(GBC) were present in 155 cholecystectomies specimens(0.8%). 67.1% of GBC are at T2 and T3 stage. Granulomatous cholecystitis was diagnosed in only 19 cases(0.1%). GBC were more prevalent in older patients(P < 10-6) and cholesterolosis was more prevalent in young patients(P < 10-6). There was no gender predilection for GBC(P = 0.739).Conclusions: The rate of incidental gallbladder carcinoma in our study is low, yet, we found a higher proportion of T2 and T3 carcinomas stage. Granulomatous cholecystitis may need further investigations and treatments. When a selective approch of histopathological examination of cholecystectomy specimens is used, it is important to take into account that clinical parameters are significantly associated with gallbladder cancer.Background: The histopathological examination of cholecystectomy specimens has not been standardized with a debate concerning the routine and the selective approach. The aim of this study was to assess the information obtained from routine histopathological examination of cholecystectomy specimens.Methods: All histopathological reports of cholecystectomy specimens between January 2003 and December 2016 were analyzed, including a clinical diagnosis of benign gallstone disease or cholecystitis.Results: A total of 20,584 reports were examined. The mean age of patients was 54.2 years. Patients aged more than 60 years represent 37.6% of the study population. Of all patients, 15,973(77.6%) were females.Incidental gallbladder cancers(GBC) were present in 155 cholecystectomies specimens(0.8%). 67.1% of GBC are at T2 and T3 stage. Granulomatous cholecystitis was diagnosed in only 19 cases(0.1%). GBC were more prevalent in older patients(P < 10^(-6)) and cholesterolosis was more prevalent in young patients(P < 10^(-6)). There was no gender predilection for GBC(P = 0.739).Conclusions: The rate of incidental gallbladder carcinoma in our study is low, yet, we found a higher proportion of T2 and T3 carcinomas stage. Granulomatous cholecystitis may need further investigations and treatments. When a selective approch of histopathological examination of cholecystectomy specimens is used, it is important to take into account that clinical parameters are significantly associated with gallbladder cancer.

关 键 词：CHOLECYSTECTOMY Gallbladder carcinoma ROUTINE INCIDENTAL Pathology GRANULOMAS 

分 类 号：R[医药卫生]