附加染色体异常的t(8;21)阳性儿童急性髓细胞白血病临床分析  

Clinical analysis of additional cytogenetic abnormalities in children of acute myeloid leukemia with t(8;21)

作　　者：姚新原 赵利师 安曦洲 于洁[1] 宪莹[1] 温贤浩[1] 郭玉霞[1] 管贤敏[1] 胡艳妮[1] 肖剑文[1] YAO Xinyuan;ZHAO Lishi;AN Xizhou;YU Jie;XIAN Ying;WEN Xianhao;GUO Yuxia;GUAN Xianmin;HU Yanni;XIAO Jianwen(Department of Hematology,Children′s Hospital of Chongqing Medical University/Key Laboratory of Pediatrics in Chongq.ing/Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing 400014,China)

机构地区：[1]重庆医科大学附属儿童医院血液肿瘤科/儿科学重庆市重点实验室/儿童发育疾病研究省部共建教育部重点实验室,重庆400014

出　　处：《现代医药卫生》2018年第17期2613-2615,2618,共4页Journal of Modern Medicine & Health

基　　金：重庆市卫生和计划生育委员会课题项目(2015msxm042)

摘　　要：目的探讨附加染色体异常对儿童t(8;21)-急性髓细胞白血病(AML)临床特征及预后的影响。方法选取t(8;21)-AML患儿75例,分析附加染色体异常对患儿临床、实验室特征及对预后的影响。结果 50例(66.67%)患儿伴附加染色体异常,性染色体缺失最常见(38例)。例数较少的附加染色体异常未纳入分析,其中67例根据染色体核型分为仅有t(8;21)组(A组,25例)、t(8;21)仅伴性染色体缺失组(B组,28例)和复杂核型组(C组,14例)。3组患儿发病年龄、性别构成、初诊白细胞、血红蛋白及乳酸脱氢酶水平、骨骼X线片异常比例及细胞形态学分布比较差异均无统计学意义(P>0.05);A组血小板计数较B、C组低,差异均有统计学意义(P<0.05)。3组患儿1个疗程完全缓解率及无事件生存期比较,差异均无统计学意义(P>0.05)。结论儿童t(8;21)-AML多伴附加染色体异常,其中以性染色体缺失最常见。附加染色体异常可能不影响t(8;21)-AML患儿临床特征及预后。Objective To investigate the effect of additional chromosomal abnormalities on the clinical features and prognosis of children with t(8;21)-acute myeloid leukemia(AML).Methods Seventy-five children with t(8;21)-AML were enrolled to analyze the clinical,laboratory characteristics and prognosis of additional chromosomal abnormalities.Results Fifty patients(66.67%)had additional chromosomal abnormalities,and sex chromosome deletions were the most common(38 cases).Additional chromosomal abnormalities with fewer cases were not included in the analysis.Among them,67 cases were divided into only t(8;21)group(group A,25 cases),t(8;21)only with sex chromosome deletion group(group B,28 cases)and complex karyotype group according to karyotype(group C,14 cases).There were no significant differences in age,gender composition,newly diagnosed white blood cells,hemoglobin and lactate dehydrogenase levels,abnormal proportion of bone X-ray films and cell morphology distribution among the 3 groups(P>0.05).Platelet counts in group A were lower than that in group B and group C,the differences were statistically significant(P<0.05).There were no significant difference in the com-plete remission rate and event-free survival among the 3 groups(P>0.05).Conclusions Children with t(8;21)-AML are of-ten associated with additional chromosomal abnormalities,with sex chromosome deletions being the most common.Additional chromosomal abnormalities may not affect the clinical features and prognosis of children with t(8;21)-AML.

关 键 词：t(8 21) 附加染色体异常 白血病 髓样 急性 儿童 

分 类 号：R733.71[医药卫生—肿瘤]