联合检测血清半胱氨酸蛋白酶抑制剂C(CystatinC)和尿中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、尿肾损伤分子-1(KIM-1)对儿童过敏性紫癜(HSP)早期肾损伤(HSPN)的诊断效能  

作　　者：施绍瑞[1] 

机构地区：[1]宜宾市第二人民医院,四川宜宾644000

出　　处：《湖南中医药大学学报》2018年第A01期855-856,共2页Journal of Hunan University of Chinese Medicine

摘　　要：目的:探究对儿童过敏性紫癜(HSP)早期肾损伤(HSPN)诊断时,应用血清半胱氨酸蛋白酶抑制剂C(CystatinC)和尿中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、尿肾损伤分子-1(KIM-1)联合检测的效能,总结经验。方法:在2015年5月到2018年1月间展开本次研究,将该时间段内65例过敏性紫癜患儿作为HSP组,将65例早期肾损伤患儿作为HSPN组,并选择同时期65例健康儿童作为对照组,分别对其实施CystatinC、NGAL、KIM-1的检测,并进行联合分析和对比。结果:HSPN组、HSP组患儿的CystatinC显著高于对照组,组间差异显著(P<0.05)。HSPN组的NGAL/uCr、KIM-1/uCr则显著高于HSP组和对照组,组间差异显著(P<0.05)。三者联合诊断的敏感性则为90.76%,明显高于单一检测(P<0.05)。结论:联合检测CystatinC、NGAL、KIM-1对儿童过敏性紫癜(HSP)早期肾损伤(HSPN)的诊断效能良好。Objective:To explore the efficacy of serum cysteine protease inhibitor C(Cystatin C)and urinary neutrophil gelatinase related lipid carrier protein(NGAL)and urinary renal injury molecule-1(KIM-1)in the diagnosis of early renal injury(HSPN)of children with allergic purpura(HSP).Methods:from May 2015 to January 2018,65 cases of Henoch Schonlein purpura were treated as HSP group,65 cases of early renal injury were taken as group HSPN,and 65 healthy children were selected as control group at the same time.The detection of Cystatin C,NGAL and KIM-1 were carried out and combined analysis and analysis were carried out.Contrast.Results:the Cystatin C in HSPN group and HSP group was significantly higher than that in the control group,and there was a significant difference between the two groups(P<0.05).The NGAL/uCr and KIM-1/uCr in group HSPN were significantly higher than those in HSP group and control group,and there was a significant difference between the two groups(P<0.05).The sensitivity of combined diagnosis of three was 90.76%,which was significantly higher than that of single detection(P<0.05).Conclusion:the combined detection of Cystatin C,NGAL and KIM-1 is effective in the diagnosis of early renal injury(HSPN)in children with Henoch Schonlein purpura(HSP).

关 键 词：血清半胱氨酸蛋白酶抑制剂 尿中性粒细胞明胶酶相关脂质运载蛋白 尿肾损伤分子-1 过敏性紫癜 早期肾损伤 

分 类 号：R735.102[医药卫生—肿瘤]