多焦视网膜电图在老龄自发性糖尿病大鼠视功能评价中的应用  

Application of multifocal electroretinogram in evaluating visual function of the elderly spontaneous diabetic rats

作　　者：李强 王红义 段俊国 LI Qiang;WANG Hongyi;Duan Junguo(College of Ophthalmology,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;Yulin Community Health Service Center of Wuhou District of Chengdu,Chengdu 610041,China)

机构地区：[1]成都中医药大学眼科学院,成都610075 [2]四川省成都市武侯区玉林社区卫生服务中心,成都610041

出　　处：《中国科技论文》2018年第12期1409-1414,共6页China Sciencepaper

基　　金：高等学校博士学科点专项科研基金资助项目(20135132120003);四川省科技厅创新苗子工程资助项目(培育项目)(2016068);成都市人口和计划生育委员会资助项目(2015019)

摘　　要：为观察老龄自发性糖尿病大鼠多焦视网膜电图的变化,按照大鼠电生理记录的标准化方案,记录GK大鼠在14月龄、15月龄、16月龄多焦视网膜电图的特征。随着月龄增加,GK大鼠血糖分别高于同月龄的Wistar大鼠,差异有统计学意义(P<0.01)。14月龄、15月龄、16月龄GK大鼠N_1波振幅密度与同月龄的Wistar大鼠比较,差别有统计学意义(P<0.05)。P_1波的振幅密度也随着月龄增加而降低,14月龄、15月龄、16月龄GK大鼠P1波振幅密度与同月龄的Wistar大鼠比较,差别有统计学意义(P<0.05)。老龄自发性糖尿病大鼠(GK大鼠)视网膜功能损害不断加重。To observe the changes of multifocal electroretinograms in elderly spontaneous diabetic rats(GK rats),based on standard stimulation and recording method,the waveform change of multifocal electroretinogram(mfERG)of the 14-month-old,the 15-month-old and the 16-month-old GK rats were recorded respectively for three month.With moon’s age gonging on,the blood glucose of GK rats is higher than that of Wistar rats with same moon’s age.There is significant difference in respective group(P<0.01).The response densities of N 1 waves in the 14-month-old,15-month-old and 16-month-old GK rats decline compared with those of Wistar rats with same moon’s age(P<0.05).The response densities of P 1 waves in the 14-month-old,15-month-old and 16-month-old GK rats decrease compared with those of Wistar rats with same moon’s age(P<0.05).The damage of vision function of the elder GK rats increase.

关 键 词：眼科学 多焦视网膜电图 自发性糖尿病大鼠 糖尿病视网膜病变 

分 类 号：R774[医药卫生—眼科]