雄激素受体表达阳性与阴性的三阴乳腺癌的钼靶X线特征  

Mammographic imaging features of triple-negative breast cancer with positive and negative expression of androgen receptor

作　　者：张惠美[1] 徐华军[2] 毛新峰[1] 朱彦[3] ZHANG Huimei;XU Huajun;MAO Xinfeng;ZHU Yan(Department of Radiology,Huzhou Central Hospital,Huzhou 313000,China;Department of Ultrasound,Huzhou Central Hospital,Huzhou 313000,China;Department of Radiology,Affiliated Hospital of Jiangsu University,Zhenjiang 212001,China)

机构地区：[1]湖州市中心医院放射科,浙江湖州313000 [2]湖州市中心医院超声科,浙江湖州313000 [3]江苏大学附属医院放射科,江苏镇江212001

出　　处：《中国医学影像技术》2018年第9期1368-1371,共4页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨雄激素受体(AR)表达阳性与阴性的三阴乳腺癌(TNBC)的钼靶X线表现特征。方法回顾性分析112例TNBC患者的临床和钼靶X线资料,比较AR阳性与AR阴性TNBC肿瘤分化程度和钼靶X线表现的差异。结果 AR阴性TNBC肿瘤分化程度低于AR阳性TNBC(χ~2=6.206,P=0.045)。AR阳性TNBC钼靶X线表现为肿块型17例(17/30,56.67%),钙化型12例(12/30,40.00%),结构扭曲1例(1/30,3.33%);AR阴性TNBC钼靶X线表现为肿块型66例(66/82,80.49%),钙化8例(8/82,9.76%),不对称性致密8例(8/82,9.76%),二者差异有统计学意义(χ~2=18.593,P<0.001)。肿块型病变中,AR阳性TNBC以不规则形为主,而AR阴性者以不规则形和圆形或椭圆形为主,二者差异有统计学意义(χ~2=11.615,P=0.003)。AR阳性与AR阴性TNBC间钙化类型无明显差异(χ~2=0.108,P=0.743),均以细小多形性钙化为主。结论 AR阴性TNBC分化较差,乳腺X线片表现不典型,肿块外形不规则和伴钙化可列入鉴别AR阴性与AR阳性TNBC的要点。Objective To explore the mammographic features of triple-negative breast cancer(TNBC)with positive and negative expression of androgen receptor(AR)expression.Methods The mammography and clinical data of 112 TNBC patients were analyzed retrospectively.The tumor differentiation and imaging features were compared between AR-positive and AR-negative TNBC.Results Tumor differentiation in AR-negative TNBC was poorer than in AR-positive TNBC(χ2=6.206,P=0.045).The mammographic features of AR-positive TNBC included mass(17/30,56.67%),calcifications(12/30,40.00%)and architectural distortion(1/30,3.33%),while in AR-negative TNBC included mass(66/82,80.49%),calcifications(8/82,9.76%)and density asymmetry(8/82,9.76%),the presences of lesion types were statistically different between AR-negative and AR-positive TNBC(χ2=18.593,P<0.001).AR-negative TNBC were more likely to present as masses with round,oval or irregular shape,while AR-positive TNBC were more likely to present as masses with of irregular shape,the presences of mass shape were statistically different between AR-negative and AR-positive TNBC(χ2=11.615,P=0.003).The mammographic findings in morphology calcification showed that both AR-negative and AR-positive TNBC were more likely to be fine pleomorphic(χ2=0.108,P=0.743).Conclusion AR-negative TNBC tend to have poor differentiation,while the features of mammography are atypical.Mammographic calcifications and irregular shapes maybe the key points of differential diagnose of AR-negative and AR-positive TNBC.

关 键 词：三阴乳腺癌 雄激素受体 乳房X线摄影术 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤] R814.41[医药卫生—临床医学]