双歧杆菌四联活菌片联合雷贝拉唑治疗Hp阳性浅表性胃炎患者的临床效果  

Bifidobacterium quadruple live bacteria tablets combined with rabeprazole in treatment of Hp-positive superficial gastritis

作　　者：张蕾[1] 黄德峰[1] Zhang Lei;Huang Defeng(Department of Gastroenterology,Luohe Central Hospital,Luohe 462000,China)

机构地区：[1]漯河市中心医院消化内科,462000

出　　处：《国际医药卫生导报》2018年第18期2787-2791,共5页International Medicine and Health Guidance News

摘　　要：目的 探究双歧杆菌四联活菌片联合雷贝拉唑治疗幽门螺杆菌(Hp)阳性浅表性胃炎患者的临床效果。方法 选取2014年6月至2017年3月本院Hp阳性浅表性胃炎患者78例,随机数字表法分为对照组与实验组,各39例。对照组雷贝拉唑治疗,实验组雷贝拉唑+双歧杆菌四联活菌片治疗,均持续治疗4周。疗程结束后,统计两组治疗效果、不良反应情况,并对比两组胃黏膜恢复效果及胃蛋白酶原I(PGI)、胃蛋白酶原II(PGII)水平;疗程结束后1个月,以13C-尿素呼气试验检查两组Hp根除率,随访6个月,统计两组疾病复发率。结果 实验组治疗效果较对照组良好,且治疗总有效率较对照组高[94.87%(37/39)比76.92%(30/37),P<0.05];实验组疗程结束后血清PGI、PGII水平较对照组低(均P<0.05);实验组疗程结束后胃黏膜组织活动性、慢性炎症评分均较对照组低(均P<0.05);实验组不良反应发生率与对照组相比[17.95%(7/39)比10.26%(4/39)],差异无统计学意义(P>0.05);疗程结束后1个月,实验组Hp根除率较对照组高[89.74%(35/39)比71.79%(28/39),P<0.05];随访6个月,实验组疾病复发率较对照组低[5.13%(2/39)比23.08%(9/39),P<0.05]。结论 Hp阳性浅表性胃炎患者联合采用雷贝拉唑、双歧杆菌四联活菌片治疗,可有效促进胃黏膜恢复,提高Hp根除率,降低血清PGI、PGII水平,降低疾病复发率,效果较为显著,且安全性较高,值得临床推广应用。Objective To investigate the clinical effect of bifidobacterium quadruple live bacteria tablets combined with rabeprazole in the treatment of patients with Helicobacter pylori(Hp)-positive superficial gastritis. Methods 78 patients with Hp-positive superficial gastritis treated at our hospital from June,2014 to March,2017 were randomly divided into a control group and an experimental group.The control group were treated with rabeprazole,and the experimental group with rabeprazole and bifidobacterium quadruple live bacteria tablets,for 4 weeks.After the treatment,the treatment effects and adverse reactions of the two groups were analyzed.The effect of gastric mucosal recovery and the levels of pepsinogen I(PGI)and pepsinogenⅡ(PGⅡ)in the two groups were compared.One month after the treatment,13C-urea breath test was used to examine the eradication rate of Hp of the two groups.After 6 months’follow-up,the recurrence rate of the two groups was statistically analyzed.Results The therapeutic effect of the experimental group was better than that of the control group, and the total effective rate of treatment was higher in the experimental group than in the control group[94.87%(37/39)vs.76.92%(30/37),P<0.05].The serum levels of PGI and PGⅡwere lower in the experimental group than in the control group after the treatment(P<0.05).The scores of gastric mucosal tissue activity and chronic inflammation were lower in the experimental group than in the control group after the treatment(P<0.05).There was no statistical difference in the adverse reaction rate between the experimental group and the control group[17.95%(7/39)vs.10.26%(4/39),P>0.05].One month after the treatment,the eradication rate of Hp was higher in the experimental group than in the control group[89.74%(35/39)vs.71.79%(28/39),P <0.05].After 6 months’follow-up,the disease recurrence rate was lower in the experimental group than in the control group[5.13%(2/39)vs.23.08%(9/39),P<0.05].Conclusion Bifidobacterium quadruple live bacteria tablets c

关 键 词：Hp阳性浅表性胃炎 双歧杆菌四联活菌片 雷贝拉唑 HP根除率 疾病复发率 

分 类 号：R573.3[医药卫生—消化系统]