GPⅢa基因PIA1/A2多态性与急性脑梗死相关性的系统评价  

Correlation between The PIA1/A2 Polymorphism of Glycoprotein Ⅲa and Acute Stroke:A Meta-Analysis

作　　者：牛文秀 尹榕[1] 杨志奇 岳金斌 NIU Wen-xiu;YIN Rong;YANG Zhi-qi;YUE Jin-bin(Department of Neurology,Lanzhou Military Region General Hospital,Lanzhou 730050,China)

机构地区：[1]兰州军区兰州总医院神经内科,兰州730050

出　　处：《循证医学》2018年第4期241-250,256,共11页The Journal of Evidence-Based Medicine

基　　金：甘肃省自然科学基金资助项目(1506RJZA302)

摘　　要：目的采用Meta分析的方法评价血小板糖蛋白Ⅲa基因PIA1/A2多态性与急性脑梗死的相关性。方法检索Pub Med、EMBASE、Web of Science、Cochrane图书馆、中国生物医学文献数据库及世界卫生组织临床注册平台,查找2017年7月以前关于GPⅢa基因PIA1/A2多态性与急性脑梗死相关性的病例对照研究。应用Rev Man5.2软件完成Meta分析。结果共纳入29篇病例对照研究,包括7 036例脑梗死病例和8 484例对照者。分析数据得出以下结论:(1)GPⅢa基因PIA1/A2多态性与急性脑梗死发病风险相关性无统计学意义[比值比=1.09,95%可信区间(0.91,1.30),P=0.36]。(2)GPⅢa基因PIA1/PIA2多态性与不同人种及地区的脑梗死发病风险相关性无统计学意义:欧洲人群的比值比=0.96,95%可信区间(0.79,1.15),P=0.64;亚洲人群的比值比=1.64,95%可信区间(0.86,3.12),P=0.13;美洲人群的比值比=0.98,95%可信区间(0.76,1.26),P=0.85;整体分析结果的比值比=1.03,95%可信区间(0.88,1.22),P=0.69。(3)GPⅢa基因PIA1/A2多态性与脑梗死病因的相关性无统计学意义:大动脉粥样硬化型的比值比=1.97,95%可信区间(0.82,4.76),P=0.13;小动脉闭塞型的比值比=1.10,95%可信区间(0.78,1.55),P=0.59;心源性栓塞型的比值比=0.85,95%可信区间(0.64,1.14),P=0.27;整体分析结果的比值比=1.21,95%可信区间(0.84,1.75),P=0.31。(4)GPⅢa基因PIA1/A2多态性与≤45岁脑梗死患者的发病风险相关性无统计学意义[比值比=0.96,95%可信区间(0.72,1.27),P=0.78]。结论 GPⅢa基因PIA1/A2多态性并不增加急性脑梗死的发病风险,且与人种、地区及年龄均无关,同时与引起脑梗死的不同病因无直接相关性。Objective To evaluate the relationship between glycoproteinⅢa gene PIA1/A2 polymorphism and acute stroke by meta-analysis.Methods The case-control studies about the correlation between the PIA1/A2 polymorphism of glycoproteinⅢa and acute stroke were retrieved from PubMed,EMBASE,Web of Science,Cochrane Library,China Biology Medicine disc and clinical trial before July 2017.And we analyzed the data using Review Manager(version 5.2).Results 29 case-control studies were included,involving 7 036 stroke patients and 8 484 controls.After data analysis the conclusion were following aspects:①There was no statistical significance between the PIA1/A2 polymorphism of glycoproteinⅢa and acute stroke[OR=1.09,95%CI(0.91,1.30),P=0.36].②There was no statistical significance between the PIA1/A2 polymorphism of glycoproteinⅢa and acute stroke within different ethnic or region,including European[OR=0.96,95%CI(0.79,1.15),P=0.64],Asian[OR=1.64,95%CI(0.86,3.12),P=0.13]and American[OR=0.98,95%CI(0.76,1.26),P=0.85].Overall analysis results[OR=1.03,95%CI(0.88,1.22),P=0.69].③It showed that there was no statistical significance between the PIA1/A2 polymorphism of glycoproteinⅢa and the pathogeny of stroke.Large artery atherosclerosis[OR=1.97,95%CI(0.82,4.76),P=0.13],small artery occlusion[OR=1.10,95%CI(0.78,1.55),P=0.59],cardiac embolism[OR=0.85,95%CI(0.64,1.14),P=0.27],Overall analysis results[OR=1.21,95%CI(0.84,1.75),P=0.31].④There was no statistical significance between the PIA1/A2 polymorphism of glycoproteinⅢa and stroke patients of age less than or equal to 45[OR=0.96,95%CI(0.72,1.27),P=0.78].Conclusion To date,it has not found the PIA1/A2 polymorphism of glycoproteinⅢa is the risk of acute stroke.The PIA1/A2 polymorphism of glycoproteinⅢa has no correlation with race,region,age and the pathogeny of stroke.

关 键 词：血小板糖蛋白Ⅲa GPⅢa基因多态性 脑梗死 整合素Β3 Meta分析 

分 类 号：R743.33[医药卫生—神经病学与精神病学]