雷替曲塞与奥沙利铂治疗头颈部鳞癌的疗效观察  

Effect of Raltitrexed and Oxaliplatin in Squamous Cell Carcinoma of the Head and Neck

作　　者：杨帆[1] 李德凡[1] 蒋淑年[1] 徐秀娟[1] 刘冰[1] YANG Fan;LI Defan;JIANG Shunian;XU Xiujuan;LIU Bing(Department of Radiation Therapy,The Second People's Hospital of Lianyungang,Lianyungang Jiangsu 222023,China)

机构地区：[1]江苏省连云港市第二人民医院放疗科,江苏连云港222023

出　　处：《中国继续医学教育》2018年第27期137-139,共3页China Continuing Medical Education

摘　　要：目的探究雷替曲塞与奥沙利铂放化疗方案在中晚期头颈部鳞癌中的治疗效果及不良反应。方法选取2013年1月—2016年3月在我院接受治疗的78例中晚期头颈部鳞癌患者,根据数字量表法随机分为对照组:40例接受5-氟尿嘧啶(5-FU)与顺铂方案(PF方案)同步放化疗;实验组:38例接受雷替曲塞与奥沙利铂方案同步放化疗。比较近期两组患者的临床疗效、不良反应与2年无进展生存率、无瘤生存率、局部控制率和总生存率。结果实验组患者治疗后客观有效率高于对照组(P<0.05);实验组局部控制率(78.9%)与总生存率(92.1%)高于对照组(P<0.05),无进展生存率与无瘤生存率差异无统计学意义(P>0.05);不良反应发生例数方面实验组均较PF方案组低,白细胞减少、恶心呕吐、肝损伤、肾损伤和脱发比较差异无统计学意义(P均>0.05),心脏毒性、皮肤反应、放射性口腔黏膜炎和过敏例数比较,差异有统计学意义(P均<0.05)。结论雷替曲塞与奥沙利铂放化疗治疗头颈部鳞癌疗效良好,不良反应较少。Objective To investigate the therapeutic efficacy of raltitrexed and oxaliplatin chemoradiation regimens in squamous cell carcinoma of the head and neck.Methods From January 2013 to March 2016,78 patients with advanced squamous cell carcinoma of the head and neck who were treated in our hospital were selected and according to the digital scale method,they were randomly divided into control group:40 patients were given 5-FU plus cisplatin regimen concurrent radiotherapy and chemotherapy;Experimental group:38 patients were given simultaneous radiotherapy and chemotherapy with raltitrex plus oxaliplatin.The clinical efficacy,2-year progression-free survival,tumor-free survival,local control,and overall survival,adverse reactions of the two groups of patients in the near future were compared.Results The effective rate of treatment in the experimental group was higher than that in the control group(P<0.05),The rate of local control(78.9%)and overall survival(92.1%)were higher in the experimental group than in the control group(P<0.05).There was no significant difference between the progression-free survival rate and the diseasefree survival rate(P>0.05).The incidence of adverse reactions was lower in the experimental group than in the PF group.There was a statistically significant difference between the two groups(P<0.05).Conclusion Raltitrexed and oxaliplatin radiotherapy for the treatment of squamous cell carcinoma of the head and neck has good short-term efficacy and fewer adverse reactions.

关 键 词：雷替曲塞 奥沙利铂 PF方案 放化疗 头颈部鳞癌 临床疗效 

分 类 号：R735[医药卫生—肿瘤]