破骨风中木脂素类化合物的分离鉴定及抗氧化活性  

Isolation,Identification and Antioxidant Activity of Lignans in Jasminum lanceolarium

作　　者：王雁冰[1] 张辉 杨峻山[3] 陈炳鹏[1] 孙佳明 WANG Yanbing;ZHANG Hui;YANG Junshan;CHEN Bingpeng;SUN Jiaming(The Second Hospital of Jilin University,Changchun 130021,China;Jilin Ginseng Academy,Changchun University of Traditional Chinese Medicine, Changchun 130117,China;Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100094,China)

机构地区：[1]吉林大学第二医院,长春130021 [2]长春中医药大学吉林省人参科学研究院,长春130117 [3]中国医学科学院药用植物研究所,北京100094

出　　处：《高等学校化学学报》2018年第9期1942-1947,共6页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:31570347)资助~~

摘　　要：以破骨风(Jasminum lanceolarium Roxb.)为研究对象,采用硅胶柱和Sephadex LH-20凝胶柱层析等手段,从中分离获得7个木脂素类化合物:Jasminlanoside A(1)、(+)-环橄榄树脂素(2)、丁香脂素-4-O-β-D-葡萄糖苷(3)、(+)-环橄榄树脂素-6-O-β-D-葡萄糖苷(4)、(+)-环橄榄树脂素-4'-O-β-D-葡萄糖苷(5)、橄榄素4″-O-β-D-葡萄糖苷(6)和丁香脂素-4,4'-O-双-β-D-葡萄糖苷(7),其中化合物1为新化合物,化合物3~6均为首次从本属植物中分离得到.利用一维核磁共振谱(1D NMR)、二维核磁共振谱(2D NMR)和高分辨电喷雾电离质谱(HR-ESI-MS)对化合物1的结构进行了鉴定.抗氧化活性测试结果表明,化合物1,2,4和5表现出一定的抗氧化活性,化合物5的1,1-二苯基-2-三硝基苯肼(DPPH)清除活性最强,IC_(50)值为(0.148±0.005)μmol/L.Using silica and Sephadex LH-20 column chromatographies,seven lignans,Jasminlanoside A(1),(+)-cycloolivil(2),syringaresinol-4-O-β-D-glucopyranoside(3),(+)-cycloolivil-6-O-β-D-glucopyranoside(4),(+)-cycloolivil-4′-O-β-D-glucopyranoside(5),(-)-olivil-4″-O-β-D-glucopyranoside(6)and syringare-sinol-4,4′-O-bis-β-D-glucopyranoside(7)were isolated from the extracts of Jasminum lanceolarium.Compound 1 was first found and compounds 3-6 were isolated from the Jasminum genus for the first time.The structure of compound 1 was determined by various spectral techniques.Compounds 1,2,4 and 5 exhibited antioxidant activity in the 1,1-diphenyl-2-picrylhydrazyl(DPPH)assay,with the highest activity in compound 5[(0.148±0.005)μmol/L].

关 键 词：破骨风 木脂素类 抗氧化活性 

分 类 号：O629.9[理学—有机化学]