共线易化效应在原发性开角型青光眼诊断中的应用研究  

The application of collinear facilitation effect to the diagnosis of patients with primary open angle glaucoma

作　　者：唐卫华 欧阳君[2] 王毓林[3] 廖文江[2] 刘康成 江会丰 谢平[2] 屈晓勇 何静[2] 叶蕾[3] 邵毅[3] TANG Wei-Hua;OU-YANG Jun;WANG Yu-Lin;LIAO Wen-Jiang;LIU Kang-Cheng;JIANG Hui-Feng;XIE Ping;QU Xiao-Yong;HE Jing;YE Lei;SHAO Yi(From the Department of Ophthalmology,the Maternal and Child Health Hospital of Jiujiang City,Jiujiang 332000,Jiangxi Province,China;Department of Ophthalmology,the First People’s Hospital of Jiujiang City,Jiujiang 332000,Jiangxi Province,China;Department of Ophthalmology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China)

机构地区：[1]九江市妇幼保健院眼科,江西省九江市332000 [2]九江市第一人民医院眼科,江西省九江市332000 [3]南昌大学第一附属医院眼科,江西省南昌市330006

出　　处：《眼科新进展》2018年第10期951-954,共4页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号:81660158、81160118、81400372);江西省重点研发项目(编号:20161BBG70019、20151BB-G70223);江西省远航工程(编号:2014022);江西省自然科学基金重大项目(编号:2016ACB21017)江西省青年科学基金(编号:20151BAB215016);江西省卫计委科技计划面上项目(编号:20155204、20175116)

摘　　要：目的通过对原发性开角型青光眼(primary open angle glaucoma,POAG)共线易化效应的观察,发现其行为特征及其与视野检查的相关性,明确共线易化效应在POAG早期诊断中的应用价值。方法选取POAG患者和正常人各12例,分别设为POAG组和对照组,对两组受试者进行视觉心理物理学试验,采用共线易化效应研究的经典刺激模式,通过心理物理学中阶梯法求阈限值,测量受试者检测阈值并应用光学相干断层扫描测量视网膜神经纤维层(retinal nerve fiber layer,RNFL)厚度。对所得数据进行统计学分析。结果对照组和POAG组受试者左眼矫正视力、左眼C/D值差异均无统计学意义(均为P>0. 05);对照组受试者左、右眼眼压,右眼C/D值均明显低于POAG组,差异均有统计学意义(均为P <0. 05);对照组右眼矫正视力明显优于POAG组右眼矫正视力,差异有统计学意义(P <0. 05)。POAG组左眼RNFL各方位厚度均明显厚于右眼,差异均有统计学意义(均为P <0. 05);而对照组左眼和右眼RNFL各方位厚度差异均无统计学意义(均为P> 0. 05)。POAG组和对照组左眼相比较,各方位RNFL厚度差异均无统计学意义(均为P> 0. 05);对照组右眼RNFL各方位厚度均厚于POAG组,差异有统计学意义(P <0. 05)。与POAG组相比,在相同距离的情况下,对照组检测阈值均明显高于POAG组,差异均有统计学意义(均为P <0. 05);且应用消色差基本刺激的条件下,POAG组和对照组检测阈值随距离的增加而增加。在各个间隔距离,对照组受试者右眼和左眼相比,随着RNFL厚度差的改变,其检测阈值无明显改变(P> 0. 05);而POAG组患者右眼和左眼相比,随着RNFL厚度差增加,各间隔距离检测阈值均明显降低,差异有统计学意义(P <0. 05);与对照组相比,POAG组RNFL厚度与检测阈值的相关系数呈明显下降趋势。结论 POAG患者的共线易化效应行为有一定的改变,可以对POAG的早期诊断提供一定的依据,对POAG的�Objective To observe the collinear facilitation effect of the patients with primary open-angle glaucoma(POAG)to find the behavioral characteristics of collinear facilitation effect of POAG and the correlation between the behavioral characteristics and the field of view examination,and to clarify the application value of collinear facilitation effect early diagnosis of POAG.Methods Twelve patients with POAG and twelve normal patients were respectively selected as the POAG group and the control group.Visual psychophysical tests were performed on both groups.The classical stimulation model studied by the collinear facilitation effect was used and the threshold value was calculated by the ladder method in psychophysics.The subject detection threshold was measured and optic coherence tomography was used to measure the thickness of the retinal nerve fiber layer(RNFL).The obtained data was statistically analyzed.Results There was no statistically significant difference in the corrected vision and C/D values of the left eye between the control group and the POAG group(all P>0.05).In the control group,the intraocular pressure of the left or right eye and C/D values of the right eye of the subjects were significantly lower than those of the POAG group,and the difference was statistically significant(all P<0.05).The corrected vision of the right eye in the control group was significantly better than that of the POAG group,and the difference was statistically significant(P<0.05).The thickness of the RNFL between all orientations in the left eye of the POAG group was significantly thicker than that in the right eye,and the difference was statistically significant(all P<0.05),and there was no significant difference in the thickness of the RNFL between the left eye and the right eye in the control group(all P>0.05).The left eye of the POAG group was compared with that of the control group and there was no significant difference in RNFL thickness between all orientations(all P>0.05).The thicknesses of the RNFL at all orientation

关 键 词：原发性开角型青光眼 共线易化效应 早期诊断 

分 类 号：R775[医药卫生—眼科]