S-萘普生-水杨酰苯胺互联前药合成的实验设计  

Design of experiment on interconnected prodrug synthesis of S-naproxen-salicylaniline

作　　者：苏国琛[1] 李玲[1] 李珅[1] 牟卫伟 Su Guochen;Li Ling;Li Shen;Mu Weiwei(College of Pharmacy,Nankai University,Tianjin 300071,China;Yantai Food and Drug Inspection and Testing Center,Yantai 264670,China)

机构地区：[1]南开大学药学院,天津300071 [2]烟台市食品药品检验检测中心,山东烟台264670

出　　处：《实验技术与管理》2018年第9期67-69,共3页Experimental Technology and Management

基　　金：南开大学2017年教学改革专项(ZB1794)

摘　　要：S-萘普生属于非甾体抗炎药,但长期服用会引起胃肠道等副反应。该文用EDC/DMAP作为偶合试剂,将S-萘普生与水杨酰苯胺酯化拼合而制成前药,希望借此提高其生物利用度、降低人体副作用发生。S-naproxen is a non-steroidal anti-inflammatory drug,but long-term use will cause side effect such as gastrointestinal tract,etc.EDC/DMAP is used as a coupling reagent,and S-naproxen is esterified with salicylaniline to form a prodrug.It is hoped to improve its bioavailability and reduce the side effect of human body.

关 键 词：S-萘普生 酯化 前药 

分 类 号：R914[医药卫生—药物化学] G642.423[医药卫生—药学]