Luminal型乳腺癌患者内分泌药物治疗依从性的影响因素分析  

Analysis of Influential Factors for the Compliance of Endocrine Drug Therapy in Patients with Luminal Breast Cancer

作　　者：吴绍勇[1] 彭星辰[1] 冉启志[2] WU Shaoyong;PENG Xingchen;RAN Qizhi(Dept.of Head&Neck and Mammary Gland Oncology,West China Hospital,Sichuan University,Chengdu 610041,China;The Second Clinical Medical College,Chengdu University of TCM,Chengdu 610041,China)

机构地区：[1]四川大学华西医院头颈乳腺肿瘤科,成都610041 [2]成都中医药大学第二临床医学院,成都610041

出　　处：《中国药房》2018年第18期2528-2531,共4页China Pharmacy

基　　金：四川省科技计划项目(No.2015SZ0157);四川省卫生厅科研课题(No.YN20140010)

摘　　要：目的:了解Luminal型乳腺癌患者内分泌药物治疗依从性的现状及其影响因素,为临床提供参考。方法:选择2009年6月1日-2012年5月31日我院收治的Luminal型乳腺癌女性患者257例,在电话随访或门诊复查时采用一般情况调查问卷结合Morisky治疗依从性量表调查,并就影响内分泌药物治疗依从性的因素进行单因素分析和多因素Logistic回归分析。结果:随访期间患者死亡22例、失访17例,218例患者完成5年随访。Luminal型乳腺癌患者内分泌药物治疗的服药率随治疗时间延长而降低,坚持服药超过1年的有202例(92.7%),坚持服药超过2年的有184例(84.4%),坚持服药超过3年的有172例(78.9%),坚持服药超过4年的有158例(72.5%),坚持服药5年的有138例(63.3%)。单因素分析结果显示,患者年龄、家庭人均月收入、文化程度、婚姻状态、居住地类型、有无内科合并症均为影响其内分泌药物治疗依从性的因素(P<0.05);多因素Logistic回归分析结果显示,患者年龄、家庭人均月收入、文化程度、婚姻状态均为影响其内分泌药物治疗依从性的独立因素。结论:Luminal型乳腺癌患者内分泌药物治疗坚持服药率随治疗时间延长而呈下降趋势,患者年龄、家庭人均月收入、文化程度、婚姻状态均是影响其内分泌药物治疗依从性的独立因素。因此,治疗时应根据患者的自身情况给予个体化、持续、动态的治疗方案,并加强用药指导、用药教育等以提高其内分泌药物治疗依从性。OBJECTIVE:To investigate the compliance and its influential factors of endocrine drug therapy in patients with Luminal breast cancer,and to provide reference in clinic.METHODS:A total of 257 patients with Luminal breast cancer were selected from our hospital during Jun.1st,2009-May 31st,2012.General information questionnaire combined with Morisky therapy compliance scale were used for survey during telephone follow-up or outpatient review.Single factor analysis and multiple factors Logistic regression analysis were conducted for the influential factors of endocrine drug therapy compliance.RESULTS:During the follow-up period,22 patients died,and 17 patients lost follow-up;218 patients completed 5 years of follow-up.The medieation rate of endocrine drug therapy was decreased with time.A total of 202 patients(92.7%)persisted in taking medicine for more than 1 year,184 patients(84.4%)for more than 2 years,172 patients(78.9%)for more than 3 years,158 patients(72.5%)for more than 4 years and 138 patients(63.3%)for 5 years.Univariate analysis showed that the compliance of endocrine drug therapy was influenced by patient’s age,monthly income per capita,level of education,marital status,type of residence and with or without internal medicine complication(P<0.05).Logistic regression analysis showed that patients’age,monthly income per capita,level of education,marital status were independent influential factors for the compliance of endocrine drug therapy.CONCLUSIONS:The medieation rate of endocrine drug therapy in patients with Luminal breast cancer is decreased with time.The patients’age,monthly income per capita,level of education,marital status are independent factors for the compliance of endocrine drug therapy.Therefore,it is suggested to provide individualized,continuous and dynamic therapy plan according to patients’condition,strengthen medication guidance and education,so as to improve the compliance of endocrine drug therapy.

关 键 词：Luminal型乳腺癌 内分泌药物治疗 依从性 影响因素 

分 类 号：R737.9[医药卫生—肿瘤] R588[医药卫生—临床医学]