NF-κB活化受体因子在胃癌中的表达及临床意义  

Expression and Clinical Significance of Receptor Activator of NF-κB in Gastric Carcinoma

作　　者：李冬阳 李智[1] 曲晶磊[1] 曲秀娟[1] 刘云鹏[1] LI Dongyang;LI Zhi;QU Jinglei;QU Xiujuan;LIU Yunpeng(Department of Oncology,The First Hospital,China Medical University,Shenyang 110001,China)

机构地区：[1]中国医科大学附属第一医院肿瘤内科,沈阳110001

出　　处：《中国医科大学学报》2018年第10期881-885,890,共6页Journal of China Medical University

基　　金：国家自然科学基金(81572374);辽宁省教育厅重点实验室基础研究项目(LZ2015073);辽宁省"百千万人才工程"(2014921032);辽宁省教育厅科学研究一般项目(L2012293);沈阳市重点科技研发计划(17-230-9-01)

摘　　要：目的检测NF-κB活化受体因子(RANK)蛋白在胃癌中的表达情况,分析RANK蛋白与胃癌临床病理特征的关系及其对生存的影响,旨在探讨RANK在胃癌中的表达及临床意义。方法选取中国医科大学附属第一医院2006年4月至2011年12月手术切除的胃癌组织标本232例,术前均未行放疗、化疗及免疫治疗。采集患者基本信息及手术、病理等相关信息,所有患者均接受随访。结果 RANK表达与性别、年龄、浸润深度、临床分期以及淋巴结转移等病理因素无显著相关性,与Lauren分型相关(P=0.001);在生存方面,RANK阳性的患者表现出生存劣势,无统计学差异(P=0.306)。亚组分析显示,肠型胃癌中,RANK的表达与年龄(P=0.032)和淋巴结转移度相关(P=0.032);在生存方面,RANK阳性的患者表现出生存劣势,有统计学意义(P=0.016)。结论 RANK可能是一个与胃癌发生发展相关的有价值的分子标记物,可以成为肠型胃癌诊断和治疗的一个新的作用靶点。Objective This study analyzed the correlation of RANK expression with the clinical and pathological features of gastric carcinoma,to investigate the clinical implications by using the streptavidin-peroxidase immunohistochemical technique.Methods Specimens of gastric carcinoma were collected from 232 patients who underwent surgical resection at the First Affiliated Hospital of China Medical University between April 2006 and December 2011,and did not receive preoperative radiotherapy,chemotherapy,and immunotherapy.Results The RANK expression did not correlate with sex,age,depth of invasion,lymph node metastasis,and clinical staging(P>0.05)but correlated with Lauren grade(P=0.001).In the intestinal gastric cancer analysis,the RANK expression did not correlate with sex,depth of invasion,lymph node metastasis,and clinical staging(P>0.05)but correlated with age(P=0.032)and lymph node metastasis(P=0.032).RANK status did not significantly correlate with overall survival,but the intestinal gastric cancer subgroup analysis revealed that the RANK-positive patients had a shorter survival than the RANK-negative patients(P=0.016).Conclusion We may speculate that RANK expression may be a valuable molecular marker related to the development of gastric cancer and may be a new target for the diagnosis and treatment of intestinal type gastric cancer.

关 键 词：NF-κB活化受体因子 胃癌 Lauren分型 淋巴结转移度 生存率 

分 类 号：R735[医药卫生—肿瘤]