吡啶甲酸铬衍生物的合成、安全性及降糖活性  

Syntheses, Safety and Antihyperglycemic Effects of Chromium Picolinate Derivatives

作　　者：柴杰 杨斌盛[1] 刘斌[1] CHAI Jie;YANG Bin-Sheng;LIU Bin(Institute of Molecular Science,Key Laboratory of Chemical Biology of Molecular Engineering of Education Ministry,Shanxi University,Taiyuan 030006,China)

机构地区：[1]山西大学分子科学研究所,化学生物学与分子工程教育部重点实验室,太原030006

出　　处：《无机化学学报》2018年第10期1783-1791,共9页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金(No.21271122,21571117)资助项目。

摘　　要：合成了4种新型吡啶甲酸铬衍生物并通过单晶衍射、电喷雾质谱、元素分析、电导率及红外光谱等手段对其结构进行了表征。通过循环伏安法研究了配体对配合物氧化还原活性的影响,通过Fenton-like反应观察了配合物诱发产生自由基的程度,发现其中有3个配合物诱发产生的自由基少于市售产品吡啶甲酸铬Cr(pic)3。动物活体实验表明,高剂量配合物3不会对小鼠脏器造成明显损伤,低剂量喂食能降低糖尿病小鼠的空腹血糖及低密度脂蛋白,其效果优于Cr(pic)3。Four new chromium picolinate derivatives were synthesized and characterized by X-ray crystal diffraction,ESI-MS,analytical element,conductivity and IR analysis.The effect of substituent groups on its redox property and hydroxyl radical(·OH)generation induced by the complex were investigated by cyclic voltammetry and Fenton-like reaction.As a result,three complexes generate less·OH than Cr(pic)3.Besides,acute toxicity and antihyperglycemic effect indicated that high dose of complex 3 is hypotoxic and exhibited more efficiency than Cr(pic)3 in reducing fasten blood glucose(FBG)and low density lipoprotein by low dose.CCDC:1500277,3.

关 键 词：吡啶甲酸铬 氧化还原性 安全性 降糖活性 

分 类 号：O614.411[理学—无机化学]