Wnt/Ca^(2+)信号通路在肢体缺血/再灌注损伤机制中的研究进展  

Research progress of Wnt/Ca^(2+) signaling pathway in mechanism of limb ischemia/reperfusion injury

作　　者：申震 朱付平[1] 黄勇[2] 范仪铭 周富强 潘成熙 SHEN Zhen;ZHU Fu-ping;HUANG Yong;FAN Yi-ming;ZHOU Fu-qiang;PAN Cheng-xi(Dept of Orthopedics,the First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410007,China;Dept of Orthopedics,Luoyang Orthopedic Hospital of Henan Province,Luoyang 471000,China)

机构地区：[1]湖南中医药大学第一附属医院骨科,湖南长沙410007 [2]河南省洛阳正骨医院骨科,河南洛阳471000

出　　处：《中国药理学通报》2018年第10期1344-1347,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81674008);湖南省科技厅资助项目(No 2013FJ4056)

摘　　要：Wnt/Ca^(2+)信号通路属于Wnt非经典通路,该通路的失调与细胞调亡、炎症反应等病理改变,以及许多疾病的发生、发展、转归有着密切联系。肢体缺血/再灌注损伤(LIRI)是临床工作中常遇到的一类难题,而Wnt/Ca^(2+)通路可诱使细胞内Ca^(2+)浓度升高并可活化Ca^(2+)敏感信号成分,其介导的细胞凋亡、Ca^(2+)超载和机体炎症等反应在LIRI中扮演重要角色。该文就Wnt/Ca^(2+)信号通路在LIRI病机中所起的作用进行综述。Wnt/Ca^2+signaling pathway is an integrant part of non-canonical Wnt signaling,which is closely related with initiation and progression of many pathological changes including apoptosis,calcium ion overload,inflammation and so on.Limb ischemia/reperfusion injury(LIRI)is common in clinical practice and difficult to deal with.The up-regulation of calcium concentration is induced and components sensitive to calcium are activated by Wnt/Ca^2+pathway.Additionally,Wnt/Ca^2+-medicated calcium metabolic process and inflammatory responses are involved with LIRI.Therefore,based on literature review,this present paper summarizes the role of Wnt/Ca^2+pathway in the pathological mechanism of LIRI.

关 键 词：Wnt/Ca^2+信号通路 细胞凋亡 CA^2+超载 炎症反应 肢体缺血/再灌注损伤 病理机制 

分 类 号：R-05[医药卫生] R329.25