肝硬化患者治疗前后肠道菌群的分析比较  

Comparative Analysis of Intestinal Flora Before and After Treatment in Patients With Liver Cirrhosis

作　　者：周慧芳[1] 万江丽 ZHOU Huifang;WAN Jiangli(Department of Laboratory,First People's Hospital of Kashgar,Kashgar Xinjiang 844000,China)

机构地区：[1]新疆喀什地区第一人民医院检验科,新疆喀什844000

出　　处：《中国继续医学教育》2018年第23期116-118,共3页China Continuing Medical Education

摘　　要：目的探讨肝硬化患者治疗前后的肠道菌群的变化。方法选取我院2017年4—9月收治的80例肝硬化患者为研究对象,其中30例采用常规治疗,为对照组。50例在常规治疗的基础上采用益生菌治疗,比较两组的治疗效果,治疗前后的肠道菌群、肝功能的变化。结果观察组的总有效率为86.0%,高于对照组的63.3%,差异有统计学意义(P<0.05)。观察组治疗后的ALT、AST、TBIL低于对照组,差异有统计学意义(P<0.05)。观察组治疗后的双歧杆菌、乳杆菌水平高于对照组,大肠杆菌、酵母菌水平低于对照组,差异有统计学意义(P<0.05)。结论益生菌能够改善肝硬化患者的肠道菌群失调,提高治疗效果。Objective To investigate the changes of intestinal microflora in cirrhotic patients before and after treatment.Methods 80 cirrhosis patients in our department from April to September 2017 were selected as the research objects,30 cases with routine treatment were the control group.50 cases with probiotics and routine treatment were the observation group.The therapeutic effects,the changes of intestinal flora and liver function were compared between the two groups.Results The total effective rate in the observation group was 86.0%which was higher than 63.3%in the control group,the difference was statistically significant(P<0.05).After treatment,ALT,AST and TBIL in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05);The levels of bifidobacteria and Enterococcus were higher than those in the control group,and the levels of Escherichia coli and yeast were lower than those in the control group,the difference was statistically significant(P<0.05).Conclusion Probiotics can improve intestinal flora imbalance in cirrhosis patients and improve the therapeutic effect.

关 键 词：肝硬化 肠道菌群 益生菌 肝功能 疗效 分析 

分 类 号：R575[医药卫生—消化系统]