β-纤维蛋白原455G/A基因多态性与中国汉族人群脑白质病变的关系研究  

Associations of β-fibrinogen gene 455G/A polymorphism with white matter lesions in Chinese Han population

作　　者：伏兵[1,2] 李敏[1,2] 董万利[1] FU Bing;LI Min;DONG Wanli(Department of Neurology,the First Affiliated Hospital of Soochow University,Suzhou,Jiangsu 215006,China)

机构地区：[1]苏州大学附属第一医院神经内科,江苏苏州215006 [2]连云港市第二人民医院神经内科,江苏连云港222023

出　　处：《中风与神经疾病杂志》2018年第9期796-799,共4页Journal of Apoplexy and Nervous Diseases

基　　金：连云港市科技局科研项目(SH1538);连云港市重点学科项目(SH1602)

摘　　要：目的探讨β-纤维蛋白原(FGB)-455G/A基因多态性与中国汉族人群脑白质病变(WML)的关系研究。方法纳入2014年10月~2016年3月于连云港市第二人民医院神经内科住院患者,采用改良Scheltens量表对研究对象进行WML评分,根据MRI结果分为WML组和对照组,检测研究对象FIB等实验室指标并分析其FGB-455G/A基因多态性。结果 WML组改良Scheltens量表评分与FIB水平呈正相关,差异有统计学意义(P <0.05);各基因型血浆FIB水平比较:AA组最高(4.30±0.79) g/L,其次GA组(3.95±0.65) g/L,GG组最低(3.71±0.58) g/L,差异有统计学意义(P=0.008);FGB-455 GG、GA、AA基因型频率及等位基因G、A的频率,两组间差异均无统计学意义(P> 0.05)。结论 I血浆FIB水平与WML程度呈正相关;FGB-455G/A基因多态性与血浆FIB水平相关,G-A突变升高血浆FIB水平;在中国汉族人群中,FGB-455G/A基因多态性与WML之间无显著相关性。Objective To explore the relationship between FGB-455G/A polymorphism and white matter lesions(WML)in Chinese Han population,and to investigate its role in the pathogenesis of WML.Methods Modified Scheltens scale was used to score the degree of WML obtained by MRI.According to MRI scans,patients were divided into WML group and control group.Other laboratory parameters such as fibrinogen were detected and FGB-455G/A gene polymorphism was analyzed.Results The scores of modified Scheltens scale in WML group were positively and significantly correlated with plasma fibrinogen level(P<0.05).The levels of fibrinogen in GG,GA,and AA genotypes were compared.We found that AA group had highest fibrinogen levels(4.30±0.79)g/L,followed by GA group(3.95±0.65)g/L,while GG group had lowest levels(3.71±0.58)g/L.The differences among the groups were statistically significant(P=0.008).There was no significant difference in frequencies of FGB-455 GG,GA,and AA genotype,and allele G and A between the two groups(P>0.05).Conclusion There was a positive correlation between plasma fibrinogen and the degree of WML.FGB-455G/A polymorphism was correlated with plasma fibrinogen levels,and G-A mutation increased the levels of plasma fibrinogen.There was no significant correlation between the FGB-455G/A polymorphism and WML in Chinese Han population.

关 键 词：纤维蛋白原 基因多态性 脑白质病变 危险因素 

分 类 号：Q343.1[生物学—遗传学] R742[医药卫生—神经病学与精神病学]