乳腺癌组织中Snail、Bcl-2的表达水平及其临床意义  

Expressions of Snail and Bcl-2 in breast cancers and their clinical significance

作　　者：刘平贤[1] 张浩[1] 李伟汉[1] Ping-xian Liu;Hao Zhang;Wei-han Li(Nanyang Central Hospital,Nanyang,Henan 473009,China)

机构地区：[1]河南省南阳市中心医院,河南南阳473009

出　　处：《中国现代医学杂志》2018年第23期36-41,共6页China Journal of Modern Medicine

摘　　要：目的探讨乳腺癌组织中Snail和Bcl-2蛋白的表达水平与临床病理特征及预后的相关性。方法使用免疫组织化学法分析2010~2015年在该院就诊的92例乳腺癌患者的癌组织中Snail和Bcl-2蛋白表达水平,分析2种蛋白表达的相关性,以及两者与患者临床病理特征及预后的关系。结果乳腺癌组织中Snail高表达率为62.5%,Bcl-2低表达率为57.6%,与癌旁组织蛋白表达率比较有差异(P<0.05),乳腺癌组织中Snail与Bcl-2呈负相关(P<0.05);Snail表达水平与组织学分级、淋巴结是否转移、雌激素受体(ER)及孕激素受体(PR)表达有相关性(P<0.05),Bcl-2表达水平与肿瘤大小、ER及PR有相关性(P<0.05);低表达Snail乳腺癌患者无瘤生存率为87.5%,死亡1例;高表达Snail乳腺癌患者无瘤生存率为78.3%,死亡5例,差异有统计学意义(P<0.05);高表达Bcl-2乳腺癌患者无瘤生存率为87.2%,死亡1例,低表达Bcl-2乳腺癌患者无瘤生存率为77.4%,死亡5例,差异有统计学意义(P<0.05)。结论 Snail表达水平与乳腺癌进展呈正相关,Bcl-2表达水平与乳腺癌进展呈负相关,而高表达Snail和低表达Bcl-2患者预后较差。Objective To investigate the expressions of Snail and Bcl-2 in breast cancers and their correlations with clinicopathological features and prognosis.Methods The expressions of Snail and Bcl-2 proteins in 92 patients with breast cancers treated in our hospital from 2010 to 2015 were analyzed by immunohistochemical method.The correlation between Snail and Bcl-2 protein expressions was analyzed,and their relationships with clinicopathological features and prognosis were analyzed.Results The high expression rate of Snail was 62.5%and the low expression rate of Bcl-2 was 57.6%in the breast cancer tissues,which were significantly higher than those in the paracancerous tissues(P<0.05).There was a negative correlation between Snail and Bcl-2 expressions in the breast cancer tissues(r=-0.519).In addition,the expression level of Snail was correlated with pathological stage,lymph node metastasis and the positive expressions of estrogen receptor(ER)and progesterone receptor(PR)(P<0.05);the expression of Bcl-2 was correlated with histological grade,ER and PR(P<0.05).In the breast cancer patients with low expression of Snail,the disease-free survival rate was 87.5%,1 case died;while in the breast cancer patients with high expression of Snail,the disease-free survival rate was 78.3%,5 cases died;the differences were significant(P<0.05).The disease-free survival rate of the breast cancer patients with high expression of Bcl-2 was 87.2%,1 case died;while the disease-free survival rate of the breast cancer patients with low expression of Bcl-2 was 77.4%,5 cases died,there were statistically significant differences(P<0.05).Conclusions Snail and breast cancer progression are positively correlated,Bcl-2 and breast cancer progression are negatively correlated.The patients with high expression of Snail and low expression of Bcl-2 have poor prognosis.

关 键 词：乳腺癌 B-淋巴细胞白血病-2 SNAIL 病理分期 

分 类 号：R737.9[医药卫生—肿瘤]