食管鳞癌中CDK16的表达及其临床病理意义  

Expression of CDK16 in Esophageal Squamous Cell Carcinoma and Its Clinicopathological Significance

作　　者：郑皓[1] 景嘉楠 李铁鹏 夏鑫 轩阁 董子明[1] ZHENG Hao;JING Jianan;LI Tiepeng;XIA Xin;XUAN Ge;DONG Ziming(School of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450001,China;Henan Cancer Hospital,Zhengzhou 450008,China;College of Public Health,Zhengzhou University,Zhengzhou 450001,China;Biochip Shanghai National Engineering Research Center,Shanghai 201203,China)

机构地区：[1]郑州大学基础医学院,河南郑州450001 [2]河南省肿瘤医院,河南郑州450008 [3]郑州大学公共卫生学院,河南郑州450001 [4]生物芯片上海国家工程研究中心,上海201203

出　　处：《信阳师范学院学报（自然科学版）》2018年第4期544-549,共6页Journal of Xinyang Normal University(Natural Science Edition)

基　　金：河南省高等学校重点科研项目(16A310004);郑州大学青年教师启动基金(1511328002);郑州大学国家级大学生创新创业训练计划项目(201510459071;201610459079)

摘　　要：以组织芯片为研究对象,采用免疫组织化学(Immunohistochemistry,IHC)检测细胞周期素依赖性激酶16(Cyclin Dependent Kinase 16,CDK16)在各类型食管癌(鳞癌、基底细胞样鳞癌、梭形细胞鳞癌、腺癌、腺鳞癌、未分化癌)中的表达.结果显示,CDK16在食管癌中的表达具有组织学特异性.CDK16在食管鳞癌中为强阳性表达.CDK16在食管鳞癌中的表达与肿瘤分化程度呈负相关,而且CDK16在细胞核中的表达阳性强度随着肿瘤的恶性程度呈依次递减趋势,而在细胞质中的表达阳性强度随着肿瘤的恶性程度呈依次递增趋势.另外在淋巴结中,CDK16主要以细胞核表达为主,且CDK16在淋巴结中的表达与肿瘤的临床分期呈正相关.以上结果表明,CDK16的表达与食管癌的组织学类型密切相关.CDK16在食管鳞癌中的高表达与食管鳞癌的发生、发展具有紧密的关系.The expression of cyclin dependent kinase 16(CDK16)was detected in tumor tissue microarray of various types of esophageal carcinoma(squamous cell carcinoma,basal cell-like cell carcinoma,spindle cell squamous cell carcinoma,adenocarcinoma,adeno-squamous cell carcinoma and undifferentiated carcinoma)by immunohistochemistry(IHC).The results showed that the expression of CDK16 in esophageal carcinoma has histological specificity.The expression of CDK16 in esophageal squamous cell carcinoma was strongly positive and was negatively correlated with the degree of tumor differentiation.The positive intensity of CDK16 expression in the nucleus showed a decreasing trend with the malignant degree of the tumor,and the positive intensity of CDK16 expression in the cytoplasm showed a increasing trend with the malignant degree of the tumor.In addition,CDK16 was mainly expressed in the nucleus in the lymph nodes,and the expression of CDK16 in lymph nodes was positively correlated with the clinical stage of the tumor.These findings suggest that the expression of CDK16 was closely related to the histological types of esophageal cancer.The high expression of CDK16 in esophageal squamous cell carcinoma is closely related with the occurrence and development of esophageal squamous cell carcinoma.

关 键 词：食管鳞癌 细胞周期素依赖性激酶16 组织芯片 

分 类 号：R363[医药卫生—病理学]