基于神经心理与生理学评估的精神分裂症无抽搐电休克治疗后认知功能的研究  

Cognitive function of schizophrenia patients after modified electroconvulsive therapy based on neuropsychological and physiological assessment

作　　者：刘毅 任艳萍[1] 姜玮[1] 马辛[1] Liu Yi;Ren Yanping;Jiang Wei;Ma Xin(Twelve Ward,Beijing Anding Hospital,Capital Medical University,Beijing 100088,China)

机构地区：[1]首都医科大学附属北京安定医院十二病区,北京100088

出　　处：《首都医科大学学报》2018年第5期651-656,共6页Journal of Capital Medical University

基　　金：国家重点基础研究发展计划项目(2014CB744601)~~

摘　　要：精神分裂症是精神科常见的慢性精神疾病,该疾病预后差、易复发,为家庭及社会带来沉重负担。精神分裂症的治疗措施多样,除药物治疗外,物理治疗中以无抽搐电休克治疗(modified electroconvulsive therapy,MECT)为主。尽管MECT在临床治疗中有着诸多优点,但MECT引起的认知不良反应一直是临床工作中的棘手问题。既往大多数研究认为MECT对精神分裂症患者的认知功能有损害作用。但是近年来这一传统观点正受到挑战,越来越多的研究表明,MECT在缓解症状的基础上,亦可能改善其认知功能。据此,本文总结了近年来国内外MECT对认知功能影响的研究,进而分析其对认知的影响及可能的机制。Schizophrenia is a common chronic mental illness in psychiatry.The disease has a poor prognosis and is prone to recurrence,which places a heavy burden on families and society.There are various treatments for schizophrenia.In addition to medical treatment,modified electroconvulsive therapy(MECT)is the main treatment in physical therapy.Although MECT has many advantages in treatment,the cognitive side effects caused by MECT have been a difficult problem in the clinic.Most previous studies have suggested that MECT has a detrimental effect on cognitive function in patients with schizophrenia.But this traditional view has been challenged in recent years,and more and more studies have shown that MECT may improve its cognitive function on the basis of symptom relief.Based on this,we summarize the research on the impact of MECT on cognitive function in recent years,and then analyze its impact on cognition and possible mechanisms.

关 键 词：无抽搐电休克治疗 精神分裂症 认知功能 

分 类 号：R749[医药卫生—神经病学与精神病学]