肝素对蛛网膜下腔出血后的神经保护作用的研究进展  

Research progress on neuroprotective effects of heparin after subarachnoid hemorrhage

作　　者：钱程行 武永康[1] QIAN Cheng-xing;WU Yong-kang(Neuro-surgical Dept.,the Affiliated Hospital of Yangzhou University,Yangzhou,Jiangsu 225000,China)

机构地区：[1]扬州大学附属医院神经外科,江苏扬州225000

出　　处：《实用医药杂志》2018年第10期941-945,共5页Practical Journal of Medicine & Pharmacy

摘　　要：蛛网膜下腔出血(subarachnoid hemorrhage,SAH)可引起神经炎症反应,尤其是动脉瘤破裂导致的蛛网膜下腔出血(aneurysmal subarachnoid hemorrhage,aSAH)可继发复杂性脑损伤,目前改善蛛网膜下腔出血的药物研究仍无令人满意的结果。肝素(heparin)是一种潜在有效的抗炎剂,降低患者血管痉挛和迟发性脑缺血的发生率,预防早期脑损伤以及迟发性神经衰退。其对SAH后的神经保护作用机制涉及对抗氧化应激、降低内皮素-1的信号转导和转录、减少缺血再灌注损伤,防止白细胞外渗、纠正血脑屏障功能障碍等。笔者着重对aSAH后肝素及神经保护作用之间的关系进行综述。Subarachnoid hemorrhage(SAH)can cause significant neuroinflammatory response,especially in the complicated brain injury caused by aneurysmal subarachnoid hemorrhage(aSAH).The drug research results on improving the prognosis of subarachnoid hemorrhage is still not satisfactory.In recent years,heparin has become a potential and effective anti-inflammatory agent,which can reduce the incidence of clinical vasospasm and delayed cerebral ischemia and prevent early brain injury and delayed neuropathy.There are many possible mechanisms for the neuroprotective effect of SAH,such as against oxidative stress,reducing signal transduction and transcription of endothelin-1,reducing ischemia-reperfusion injury,preventing leukocyte extravasation,and correcting the dysfunction of blood brain barrier.In this article,authors focus on the relationship between heparin and neuroprotection after aSAH.

关 键 词：肝素 蛛网膜下腔出血 神经保护作用 

分 类 号：R743.35[医药卫生—神经病学与精神病学]