Myosin 1H基因多态性与骨性下颌后缩的相关性研究  

Association of MYO1H gene polymorphism with skeletal mandibular retrognathism

作　　者：尹倩 王小琴[2] YIN Qian;WANG Xiaoqin(Taiyuan,School of Stomatology of Shanxi Medical University,030001,China;;Department of Stomatology,Shanxi Medical University First Hospital,Taiyuan)

机构地区：[1]山西医科大学口腔医学院,太原030001 [2]山西医科大学第一医院正畸科

出　　处：《实用口腔医学杂志》2018年第5期660-664,共5页Journal of Practical Stomatology

摘　　要：目的:分析Ⅰ类肌球蛋白基因(MYO1H) rs3825393位点单核苷酸多态性与骨性下颌后缩易感性的关系。方法:收集骨性下颌后缩患者(病例组) 40例和骨性Ⅰ类错牙合患者(对照组) 40例,静脉血提取DNA,应用PCR-RFLP技术测定其MYO1H基因rs3825393位点的多态分布并对它们与骨性下颌后缩患者的相互关系进行探讨。结果:AG、GG和AA型在病例组分别为24、11和5例,在对照组分别为13、24和3例(P=0. 014)。等位基因G和A在病例组分别为46和34,在对照组分别为61和19(P=0. 012)。各基因型及等位基因分布均符合Hardy-Weinberg平衡(P> 0. 05)。结论:MYO1H基因中rs3825393多态位点可能是发生骨性下颌后缩的风险因子。Objective:To investigate the relationship between Class I myosin gene(MYO1H)rs3825393 single nucleotide polymorphism(SNPs)and skeletal mandibular retraction.Methods:Genotyping of rs3825393 was conducted by PCR-based restriction fragment length polymorphism(PCR-RFLP)analysis in both 40 patients with mandibular retrognathism and 40 controls with skeletal ClassⅠmalocclusion.Results:Genotype of AG,GG and AA were observed in 24,11 and 5 cases of case group,in 13,24 and 3 cases of control group,respectively(P=0.014).Allele frenqucy of G and A was observed in 46 and 34 in the case group,in 61 and 19 in the control group,respectively(P=0.012).The genotype frequency distribution in the case group and the control group was not deviated from the Hardy-Weinberg equilibrium(P>0.05).Conclusion:The SNPs of rs3825393 in MYO1H gene may be associated with skeletal mandibular retraction in the northern Chinese population.

关 键 词：I类肌球蛋白(MYO1H) 骨性下颌后缩 基因多态性 

分 类 号：R783.5[医药卫生—口腔医学]