非酒精性脂肪肝病的易感基因及与2型糖尿病相关性的研究进展  

Research advances in susceptibility genes of non-alcoholic fatty liver disease and its association with type 2 diabetes

作　　者：杜特 陈静 沈旭[3] DU Te;CHEN Jing;SHEN Xu(Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203;University of Chinese Academy of Sciences,Beijing 100049;Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]中国科学院上海药物研究所,上海201203 [2]中国科学院大学,北京100049 [3]南京中医药大学,南京210023

出　　处：《中国药科大学学报》2018年第5期537-544,共8页Journal of China Pharmaceutical University

摘　　要：非酒精性脂肪肝病作为高发性肝脏疾病,不仅受到外界环境因素的调控,遗传因素也影响着该类疾病的发生发展。2型糖尿病作为同样受到外界环境和遗传因素影响的疾病,在信号通路变化和易感基因方面与非酒精性脂肪肝病密切相关。本文从非酒精性脂肪肝病的易感基因以及它与2型糖尿病易感基因的相关性研究和相应的临床应用进行总结,为两种疾病的机制探索提供更深层次的依据,为疾病的诊断和治疗指出新的方向。Nonalcoholic fatty liver disease(NAFLD)as the most common hepatic disease worldwide is affected not only by extrinsic factors,but also by genetic ones.Type 2 diabetes mellitus(T2DM),another chronic disease regulated by both environmental and genetic factors,is closely related to NAFLD in signal pathways and susceptibility genes.This review summarizes the susceptibility genes of NAFLD,especially points out their relevance to T2DM and suggests their related clinical applications,which provide further evidence for the exploration of the mechanisms of the two diseases with a new direction for their diagnosis and treatment.

关 键 词：非酒精性脂肪肝病 2型糖尿病 易感基因 相关性 

分 类 号：R575.5[医药卫生—消化系统] R587.1[医药卫生—内科学]