5-HT再摄取抑制剂对抑郁症患者睡眠质量和疗效的影响  

The effect of 5-HT Reuptake Inhibitors on Sleep Quality and Clinical Efficacy in Depression Patients

作　　者：杨晓钟[1] 马雯霞[1] YANG Xiaozhong;MA Wenxia(The Second Affiliated Hospital of Xi'an Medical College,Shaanxi Xi'an 710038,China)

机构地区：[1]西安医学院第二附属医院药剂科,陕西西安710038

出　　处：《河北医学》2018年第10期1630-1634,共5页Hebei Medicine

基　　金：陕西省科技计划项目;(编号:2015K15-02-10)

摘　　要：目的:本文旨在探讨5-HT再摄取抑制剂对抑郁症患者睡眠质量和疗效的影响。方法:选取2016年6月至2018年5月期间于我院就诊的中重度抑郁症患者124例作为研究对象,采用随机数字表法将其分为实验组(68例)和对照组(56例)。实验组给予5-HT再摄取抑制剂(SRI)进行治疗,对照组给予三环类抗抑郁药进行治疗。探讨两组患者在治疗1、2和4周后的总有效率,对比分析两组患者治疗前后不同时间点的匹兹堡睡眠质量指数量表(PSQI)、汉密顿抑郁量表(HAMD)和自评抑郁量表(SDS)评分差异。结果:实验组在治疗1、2和4周后的总有效率分别为85.29%、92.65%和97.05%,较对照组治疗后总有效率分别为73.21%、82.14%和89.29%相比明显升高,差异有统计学意义(P<0.05)。此外,实验组在治疗1、2和4周后的匹兹堡睡眠质量指数量表(PSQI)、汉密顿抑郁量表(HAMD)和自评抑郁量表(SDS)评分较对照组相比明显降低且远期疗效更佳,差异有统计学意义(P<0.05)。结论:5-HT再摄取抑制剂对抑郁症患者具有显著的临床疗效且安全可靠,能够有效缓解患者的抑郁症状并提高患者的睡眠质量,为今后提高抑郁症患者的生活质量提供有力的理论依据,值得临床大力推广应用。Objective:To investigate the effect of 5-HT reuptake inhibitors on sleep quality and clinical efficacy in patients with depression.Methods:From June 2016 to May 2018,124 patients with moderate to severe depression were selected as subjects.They were divided into experimental group(68 cases)and control group(56 cases)by random number table.Patients in the experimental group were treated with 5-HT reuptake inhibitor(SRI),and patients in the control group were treated with tricyclic antidepressants.The overall effectiveness and the Pittsburgh Sleep Quality Index(PSQI),Hamilton Depression Scale(HAMD)and Self-rating Depression Scale(SDS)scores of the two groups after 1,2 and 4 weeks of treatment were comparative analyzed.Results The overall effective rates of patients in the experimental group after 1,2 and 4 weeks of treatment were 85.29%,92.65%and 97.05%,respectively,which were significantly higher than that in the control group with the overall effective rates after treatment were 73.21%,82.14%and 89.29%,respectively.The difference was statistically significant(P<0.05).In addition,the Pittsburgh Sleep Quality Index(PSQI),Hamilton Depression Scale(HAMD),and Self-rating Depression Scale(SDS)scores were significantly lower in the experimental group than that in the control group after 1,2 and 4 weeks of treatment and the long-term efficacy of the experimental group was better after treatment for different periods of time.The difference were statistically significant(P<0.05).Conclusion:5-HT reuptake inhibitors have significant clinical efficacy and safety in patients with depression,which could effectively relieve patients'depressive symptoms and improve their sleep quality,providing a strong theoretical basis for improving the quality of life of depression patients in the future,is worthy for clinical promotion and application.

关 键 词：5-HT再摄取抑制剂 抑郁症 睡眠质量 

分 类 号：R749.4[医药卫生—神经病学与精神病学]