高度近视萎缩弧面积的多模态成像定量分析  

Quantitative Analysis of Multimodal Imaging of Parapapillary Atrophy in High Myopia

作　　者：王佳琳[1] 孙姣 王艳玲[1] 孟照洋[1] Jialin Wang;Jiao Sun;Yanling Wang;Zhaoyang Meng(Department of Ophthalmology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院眼科,100050

出　　处：《中华眼视光学与视觉科学杂志》2018年第10期608-612,共5页Chinese Journal Of Optometry Ophthalmology And Visual Science

摘　　要：目的:比较高度近视患者萎缩弧(PPA)面积的多模态成像定量分析结果。方法:系列病例研究。收集2016年10月至2017年10月在首都医科大学附属北京友谊医院就诊的高度近视伴萎缩弧的患者30例(45眼)。其中,男13例(19眼),女17例(26眼)。年龄27~69(53.1±11.6)岁。所有患者均行眼底彩色照相(CFP)、近红外自发荧光(NIR-FAF)、眼底荧光素血管造影(FFA)及频域光学相干断层扫描(OCT)检查。由2名眼科医师在相互独立、互不干扰的情况下分别对上述多模态成像图像进行精准定量分析。采用Image J 1.50i版软件描绘并计算CFP、FAF、FFA图像中PPA的面积。当NIR-FAF难以确定视盘和PPA边界时,用频域OCT辅助确定。医师之间多模态成像结果的一致性检验采用Bland-Altman分析。结果:CFP、NIR-FAF、FFA检查测得患眼PPA面积分别为(7.1±4.7)mm2、(8.3±5.8)mm2、(8.1±5.5)mm2。CFP、FAF、FFA 3种方法测得PPA面积差异无统计学意义(F=1.193,P=0.307)。Bland-Altman分析结果显示,2名眼科医师之间多模态成像结果的一致性较高,其变异范围CFP<NIR-FAF<FFA。结论:NIR-FAF测得高度近视PPA面积最大,FFA次之,CFP最小。Objective:To compare and quantitatively analyze the different characteristics of multimodal imaging of parapapillary atrophy(PPA)in patients with high myopia.Methods:This was a case series study that included multimodal images of 45 eyes with PPA in 30 high myopia patients.There were 13 males(19 eyes)and 17 females(26 eyes).Age ranged from 27 to 69 years,with a mean age of 53.1±11.6 years.All eyes were examined by color fundus photography(CFP),near infrared spectrum fundus autofluorescence(NIR-FAF),fundus fluorescein angiography(FFA)and spectral domain optical coherence tomography(OCT).Using image J software,two trained ophthalmologists,operating in masked fashion,graded lesions in the CFP and NIR-FAF areas independently and compared the size of the PPA area.OCT was performed to confirm the border of the lesion when NIR-FAF and FFA were difficult to determine.The consistency of the results between the two ophthalmologists was analyzed by Bland-Altman.Results:The PPA areas of CFP,NIR-FAF and FFA were 7.1±4.7 mm2,8.3±5.8 mm2,8.1±5.5 mm2.The differences in the PPA area between the three multimodal image groups were not statistically significant(F=1.193,P=0.307).The consistency of the results between the two ophthalmologists was high,with a variation range of CFP<NIR-FAF<FFA.Conclusions:The mean differences in the size of the PPA measured by CFP,NIR-FAF and FFA are not statistically significant.

关 键 词：高度近视 萎缩弧 多模态成像 近红外自发荧光 

分 类 号：R778.11[医药卫生—眼科]