青光眼睫状体炎患者角膜共聚焦显微镜表现  

In Vivo Confocal Microscopy of Corneal in Posner-Schlossman Syndrome

作　　者：洪颖[1] 王渺 任靖 肖格格[1] 洪晶[1] Ying Hong;Miao Wang;Jing Ren;Gege Xiao;Jing Hong(Department of Ophthalmology,Beijing Key Laboratory of Visual Injury and Restoration,Peking University Third Hospital,Beijing 100191,China;Department of Ophthalmology,Beijing Children's Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院眼科北京市视觉损伤与修复重点实验室,100191 [2]北京市儿童医院眼科,100191

出　　处：《中华眼视光学与视觉科学杂志》2018年第10期627-631,共5页Chinese Journal Of Optometry Ophthalmology And Visual Science

摘　　要：目的:应用活体共聚焦显微镜(IVCM)观察青光眼睫状体炎(又称Posner-Schlossman综合征,PPS)患者角膜组织形态学改变。方法:回顾性研究。对2014年5月至2017年5月于北京大学第三医院眼科就诊的56例PPS患者(56眼)的病历资料进行归纳整理,记录患者的视力、眼压、裂隙灯显微镜检查结果及共聚焦显微镜下表现,包括角膜基质细胞有无活化、内皮细胞形态、有无角膜后沉着物(KP)及KP的形态、有无朗格罕氏细胞(LCs)及其形态特点。采用卡方检验进行数据分析。结果:56例PSS患者LogMAR视力为0.3±0.2,眼压为(29.7±13.4)mmHg,使用青光眼药物的种类为(2.6±1.0)种。全部患者受累眼角膜内皮细胞呈六角形。50例患者(89%)的患眼可以观察到角膜基质细胞活化;32例患者(57%)的患眼可以观察到内皮面LCs;44例患者(79%)的患眼可观察到KP,共6种类型。以上与对侧眼相比,差异均具有统计学意义(分别为χ2=69.14,41.29,60.89,P<0.001)。结论:IVCM下可见PSS患者的角膜基质细胞活化,内皮面出现LCs及多种类型的KP。Objective:To investigate the in vivo confocal microscopy(IVCM)findings of corneal in Posner-Schlossman syndrome(PSS)patients.Methods:In this retrospective study,the record of 56 PSS patients(56 eyes)who visited Peking University Third Hospital Ophthalmology Department from May 2014 to May 2017 were reviewed.Data of visual acuity,intraocular pressure(IOP),keratic precipitate(KP)and IVCM results were recorded.IVCM examination included corneal stromal cell activation,corneal endothelium cell change,the morphology of KPs and the morphology of Langerhans cells(LCs).Statistical analysis was performed by a chi-square test.Results:Visual acuity of the 56 PSS patients was 0.3±0.2(LogMAR),and IOP was 29.7±13.4 mmHg with 2.6±1.0 anti-glaucoma medications.IVCM identified 50 patients(89%)who had keratocyte activation of the affected eyes.LCs could be seen in 32 patients(57%)of the affected eyes and 6 types of KP could be observed in 44 patients(79%)of the affected eyes.There was a statistically significant difference with contralateral eyes(χ2=69.14,41.29,60.89,P<0.001).The corneal endothelial cells of all patients were hexagon.Conclusions:Keratocyte activation,LCs in the endothelium layer and different types of KP could be seen in PSS patients.

关 键 词：青光眼睫状体炎 共聚焦显微镜 角膜后沉着物 朗格罕氏细胞 

分 类 号：R775[医药卫生—眼科]