脑室周围白质损伤患者执行功能损害与日常生活活动能力的相关性  

Correlation between Executive Function and Activities of Daily Living for Patients with Periventricular White Matter Lesions

作　　者：王金芳[1,2] 王万铭 陈红燕 叶娜[1] 马艳玲[1] 张玉梅[1] WANG Jin-fang;WANG Wan-ming;CHEN Hong-yan;YE Na;MA Yan-ling;ZHANG Yu-mei(Department of Neurology,Beijing Tiantan Hospital,Capital Medical University;China National Clinical Research Center for Neurological Diseases;Center of Stroke,Beijing Institute for Brain Disorders;Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease,Beijing 100050,China;Department of Neurology,General Hospital of The Yangtze River Shipping,Wuhan Brain Hospital,Wuhan,Hubei 453100,China;Department of Neuroimaging,Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京天坛医院神经病学中心血管神经病学科,国家神经系统疾病临床医学研究中心,北京脑重大疾病研究院脑卒中研究所,脑血管病转化医学北京市重点实验室,北京市100050 [2]长江航运总医院,武汉脑科医院神经内科,湖北武汉市453100 [3]首都医科大学附属北京天坛医院影像科,北京市100050

出　　处：《中国康复理论与实践》2018年第10期1182-1186,共5页Chinese Journal of Rehabilitation Theory and Practice

基　　金：国家自然科学基金项目(No.81371201);首都医科大学基础与临床合作重点项目(No.16JL03);北京市医院管理局临床医学发展专项经费资助(No.ZYLX201836);湖北省卫生计生委科研项目(No.WJ2017F057;No.WJ2017M208)。

摘　　要：目的探讨脑室周围白质损伤(PWMLs)患者执行功能损害与日常生活活动能力之间的关系。方法 2016年1月至2017年1月,PWMLs患者及正常对照者各35例,采用执行功能评估量表和日常生活活动能力量表(ADL)进行评估,并分析两者之间关系。结果与正常对照组比较,PWMLs组简易精神状态检查(MMSE)、蒙特利尔认知评估(MoCA)评分显著降低(t>13.726, P<0.001),交替连线测验时间和Stroop色词检验时间显著延长(t>6.817, P<0.001),语言流畅性测验评分降低(t=6.891, P=0.013),数字符号转换评分无显著性差异(t=3.372, P=0.072)。PWMLs组ADL评分较正常对照组显著增高(t=76.413, P<0.001)。PWMLs组执行功能Z分与ADL评分呈正相关(r=0.438, P=0.008)。结论 PWMLs患者存在执行功能损害及日常生活活动能力下降,其日常生活活动能力下降与执行功能损害的严重程度相关。Objective To study the relationship between executive function and activities of daily living for patients with periventricular white matter lesions(PWMLs).Methods From January,2016 to January,2017,35 PWMLs patients and 35 normal controls were collected.Their executive function and activities of daily living were assessed with neuropsychological tests and Activities of Daily Living Scale(ADL).Results Compared with the normal control group,the scores of Mini-Mental State Exam(MMSE)and Montreal Cognitive Assessment(MoCA)significantly decreased(t>13.726,P<0.001),the times of Trail-Making Test and Stroop Colour Word Test significantly lengthened,the Verbal Fluency Test score decreased(t=6.891,P=0.013)and the Digit-Symbol Substitution Test score did not improve(t=3.372,P=0.072)in PWMLs group.The Z score of executive function was positively correlated with ADL score(r=0.438,P=0.008).Conclusion The executive function and activities of daily living are impaired in PWMLs patients,and their activities of daily living is related to the severity of the executive function impairment.

关 键 词：脑室周围白质损伤 认知功能损害 执行功能 日常生活活动能力 

分 类 号：R742[医药卫生—神经病学与精神病学]