ICAM-1在NF-κB通路中表达的研究进展  

Research Progress of Intercellular Adhesion Molecule^(-1) Expression in NF-κB Pathway

作　　者：韩玉梅 谢晶莹[1,3] 邓盈盈[2] 冯若飞 HAN Yu-mei;XIE Jing-ying;DENG Ying-ying;FENG Ruo-fei(Key Bio-engineering and Technology Laboratory of the Northwest Minzu University,Lanzhou,730030,China;Gansu Engineering Research Center for Animal Cell,Lanzhou,730030,China;Life Science and Engineering College,Northwest Minzu University,Lanzhou,730030,China)

机构地区：[1]西北民族大学生物工程与技术国家民委重点实验室,甘肃兰州730030 [2]西北民族大学生命科学与工程学院,甘肃兰州730030 [3]甘肃省动物细胞工程技术研究中心,甘肃兰州730030

出　　处：《西北民族大学学报（自然科学版）》2018年第3期40-45,共6页Journal of Northwest Minzu University(Natural Science)

基　　金：国家自然科学基金项目(31460665;31702234);教育部"创新团队发展计划"项目(IRT_17R88);西北民族大学"双一流"引导专项生物工程特色学科(10018703;1001070204)

摘　　要：细胞间黏附分子(intercellular adhesion molecule-1,ICAM-1),属于免疫球蛋白超家族中的一员,其主要功能是参与白细胞的迁移,来作为T淋巴细胞活化信号和调节炎性因子的表达.因此,ICAM-1表达量的变化与机体多种疾病相关.ICAM-1启动子区域含有大量能与转录因子及协同刺激物结合的基因位点,因而多种信号通路及转录因子参与调节ICAM-1的转录表达.NF-κB通路作为重要的炎症信号通路,同样也是调控ICAM-1表达的一条关键性转录通路.在炎症、病毒及肿瘤等疾病条件下,多种细胞因子能够通过激活NF-κB通路,从而改变ICAM-1的基因及蛋白表达水平.同时,ICAM-1作为疾病治疗中重要的靶点,为疾病的治疗开辟了新的道路.Intercellular adhesion molecule-1(ICAM-1)is a member of the immunoglobulin superfamily.Its main function is to participate in the migration of leukocytes,as an activation signal of T lymphocytes and to regulate the expression of inflammatory factors.Therefore,changes in ICAM-1 expression are associated with a variety of diseases in the body.ICAM-1 promoter region contains a large number of gene loci that can bind to transcription factors and co-stimulants,and thus a variety of signaling pathways and transcription factors are involved in regulating the transcriptional expression of ICAM-1.NF-kappa B pathway as an important inflammatory signaling pathway and is also a key transcriptional pathway regulating ICAM-1 expression.Under the conditions of inflammation,viruses and tumors,many cytokines can alter the expression of ICAM-1 genes and proteins by activating the NF-κB pathway.At the same time,ICAM-1 as an important target in the treatment of diseases has opened up a new path for the treatment of diseases.This article made a brief review on the expression form of ICAM-1 and its expression in the NF-κB pathway.

关 键 词：ICAM-1 NF-ΚB通路 炎症 调节 治疗 

分 类 号：R730[医药卫生—肿瘤]