大柴胡颗粒联合盐酸氨溴索治疗脑出血急性期并发肺部感染的临床研究  

Clinical Research on Dachaihu Granule and Ambroxol Hydrochloride in the Treatment of Acute Cerebral Hemorrhage Complicated with Pulmonary Infection

作　　者：谢三平[1] 谭显红[1] 王彦丽[1] 陈立[1] Xie Sanping;Tan Xianhong;Wang Yanli;Chen Li(Jingzhou Central Hospital,Jingzhou 434020,Hubei,China)

机构地区：[1]荆州市中心医院,湖北荆州434020

出　　处：《中西医结合心脑血管病杂志》2018年第19期2793-2797,共5页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：湖北省自然科学基金资助项目(No.2013CFB130)

摘　　要：目的研究大柴胡颗粒联合盐酸氨溴索治疗脑出血急性期并发肺部感染的临床效果。方法选取2014年5月—2015年11月我院收治的80例脑出血急性期并发肺部感染病人作为研究对象,随机分为两组。对照组40例,在脱水降颅内压、营养支持、脑保护、调节水电解质平衡、吸痰等常规治疗基础上,加用盐酸氨溴索治疗;治疗组40例,在对照组治疗基础上加用大柴胡颗粒进行联合治疗。治疗2周后,比较两组病人治疗前后体征积分、症状积分、血清炎症因子、血压水平及治疗效果。结果治疗组病人治疗总有效率(85.0%)高于对照组总有效率(65.0%),差异有统计学意义(P <0.05);治疗组呼吸、啰音、哮鸣音积分均低于对照组,差异有统计学意义(P <0.05);治疗组咳嗽、咳痰、喘息积分均低于对照组,差异有统计学意义(P <0.05);治疗组白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)水平均低于对照组,差异有统计学意义(P <0.05);治疗组舒张压、收缩压均低于对照组,血氧饱和度高于对照组,差异有统计学意义(P <0.05)。结论采用大柴胡颗粒联合盐酸氨溴索治疗脑出血急性期并发肺部感染能有效缓解临床症状,减轻病情,预防或减少并发肺部感染。Objective To investigate the effect of Dachaihu granules(DCHG)and ambroxol hydrochloride in the treatment of acute cerebral hemorrhage complicated with pulmonary infection.Methods Eighty patients with acute cerebral hemorrhage complicated with pulmonary infection in the hospital from May 2014 to November 2015 were selected and randomly divided into two groups:control group(n=40)treated with ambroxol hydrochloride,and treatment group(n=40)treated with DCHG and ambroxol hydrochloride in the basis of routine treatment for 2 weeks.After 2 weeks of treatment,the symptom scores,syndrome scores,serum inflammatory factors,blood pressure levels and treatment effects were observed before and after treatment.Results The total effective rate in treatment group was higher than that in control group(85.0%vs 65.0%,P<0.05).The scores of breath,rale,and wheeze in treatment group were lower than that in control group(P<0.05).The scores of cough,expectoration,gasp in treatment group were lower than that in control group(P<0.05).The levels of interleukin(IL)6,tumor necrosis factorα(TNFα),and high sensitivity C reactive protein(hs CRP)in the treatment group were lower than those in the control group(P<0.05).The diastolic blood pressure and systolic blood pressure in the treatment group were lower than those in the control group,and the blood oxygen saturation in the treatment group was higher than that of the control group(P<0.05).Conclusion DCHG and ambroxol hydrochloride can effectively alleviate clinical symptoms,and prevent or reduce the occurrence of pulmonary infection in patients with acute cerebral hemorrhage complicated with pulmonary infection.

关 键 词：脑出血 大柴胡颗粒 盐酸氨溴索 急性期 肺部感染 炎性因子 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R255.2[医药卫生—临床医学]