3～6岁儿童血清维生素A、D、E水平分析  

Serum vitamin A, D and E levels in children aged 3-6 years

作　　者：唐红梅[1] 孙晓艳[1] 王芳[1] 肖霞[1] 顾翼洋 TANG Hong-mei;SUN Xiao-yan;WANG Fang;XIAO Xia;GU Yi-yang(Department of Health Education and Information Monitoring,Jiaxing Maternity and Child Health Care Hospital,Jiaxing,Zhejiang 314000,China)

机构地区：[1]嘉兴市妇幼保健院健康教育信息监测科,浙江嘉兴314000

出　　处：《预防医学》2018年第11期1116-1119,共4页CHINA PREVENTIVE MEDICINE JOURNAL

基　　金：嘉兴市科技计划项目(2016BY28027)

摘　　要：目的了解嘉兴市南湖区3～6岁儿童维生素A、 D、 E水平,为预防儿童维生素营养缺乏提供依据。方法选择嘉兴市南湖区36所幼儿园的3～6岁儿童,采用高效液相色谱法测定维生素A (VA)和维生素E (VE),采用串联质谱法测定血清25-羟基维生素D [25 (OH) D];分析不同性别、年龄儿童维生素A、 D、 E营养水平。结果共调查3 414名3～6岁儿童,其中男童1 859人,占54.45%;女童1 555人,占45.55%。血清VA为0.35 (0.09)μg/m L,不足率为18.31%,缺乏率为0.88%;血清25 (OH) D为23.00 (7.70) ng/mL,不足率为22.55%,缺乏率为7.00%;血清VE为7.80 (2.00) mg/L,不足率为2.46%,缺乏率为1.00%。血清VA正常、不足、缺乏构成男女童差异无统计学意义(P<0.05);女童25 (OH) D缺乏和不足比例均高于男童(P<0.05); VE缺乏和不足比例低于男童(P<0.05)。不同年龄组儿童VA和25 (OH)的正常、不足和缺乏构成差异均有统计学意义(P<0.05);不同年龄组VE正常、不足、缺乏构成差异无统计学意义(P>0.05)。结论嘉兴市南湖区3～6岁儿童维生素A、 D、 E水平缺乏或不足均占一定比例;男女童VD、 VE水平存在差异。Objective To understand the levels of vitamins A,D and E in children aged 3-6 years in Nanhu District of Jiaxing,to provide a basis for preventing vitamin deficiency in children.Methods Children in 36 kindergartens in Nanhu District of Jiaxing were selected for serum vitamin determination.The concentrations of vitamin A(VA)and vitamin E(VE)were determined by high performance liquid chromatography(HPLC).The levels of serum 25-hydroxyvitamin D[25(OH)D]were determined by tandem mass spectrometry.The vitamin levels of children of different genders and ages were analyzed.Results A total of 3 414 children aged 3-6 years were selected,which included 1 859 boys,accounting for 54.45%;and 1 555 girls,accounting for 45.55%.The serum VA level was 0.35(0.09)μg/mL,the rate of insufficient detection was 18.31%,the lack rate was 0.88%;the serum 25(OH)D level was 23.00(7.70)ng/mL,the rate of insufficient detection was 22.55%,and the lack rate was 7.00%;the serum VE level was 7.80(2.00)mg/L,the rate of insufficient detection was 2.46%,and the lack rate was 1.00%.There was no significant difference in the normal rate,the rate of insufficient detection,and the lack rate of serum VA between boys and girls(P>0.05).The rate of insufficient detection and the lack rate of 25(OH)D in girls were significantly higher than boys(P<0.05).The rate of insufficient detection and the lack rate of VE in girls were significantly lower than boys(P<0.05).The normal rate,the rate of insufficient detection and the lack rate of VA and 25(OH)D in children aged 3-6 years increased with age(P<0.05).The normal rate,the rate of insufficient detection and the lack rate of VE showed no trend with age(P>0.05).Conclusion A certain proportion of children aged 3-6 years in Nanhu District had deficiency in vitamin A,D and E.The VD and VE levels between boys and girls were different.

关 键 词：儿童 维生素A 25-羟基维生素D 维生素E 缺乏 

分 类 号：R153.2[医药卫生—营养与食品卫生学]