急性闭角型青光眼发病相关危险因素研究  

Significances of host risk factors for acute angle-closure glaucoma

作　　者：李中庭 冷炫 李乃洋[2] 赵岐[2] 余敏斌[1] LI Zhong-Ting;LENG Xuan;LI Nai-Yang;ZHAO Qi;YU Min-Bin(State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangzhou 510020,Guangdong Province,China;Department of Ophthalmology,Zhongshan City People’s Hospital,Zhongshan 528400,Guangdong Province,China)

机构地区：[1]中山大学中山眼科中心,眼科学国家重点实验室,广东省广州市510020 [2]中山市人民医院,眼科医疗中心,广东省中山市528400

出　　处：《眼科新进展》2018年第11期1062-1065,共4页Recent Advances in Ophthalmology

基　　金：广州市科技计划(编号:2014Y2-00172;2014A020212052);中山市科技计划(编号:20122A003;201581115)~~

摘　　要：目的探讨急性闭角型青光眼(acute angle-closure glaucoma,AACG)发病相关的危险因素,为早期筛查和干预AACG患者提供较为可靠的依据。方法收集2013年6月至2015年7月在中山市人民医院眼科就诊的AACG患者,对照组为无其他眼部疾病及系统性疾病的正常志愿者。对AACCG组患者未发作眼及对照组双眼应用Pentacam眼前节分析系统测量角膜曲率、前房相关参数,应用IOL Master测量眼轴长度和角膜直径,应用光学相干断层扫描仪(optical coherence tomography,OCT)测量视网膜神经纤维层厚度等参数。研究并分析这些参数与AACG发病间的关系。结果AACG组角膜直径为(11.57±0.39) mm,前房深度为(1.88±0.43) mm,前房容积为(75. 34±36.49) mm^3,前房角度数为(25.26±7. 67)°,眼轴长度为(22. 16±1. 03) mm,下方视网膜神经纤维层厚度为(118.38±34.78)μm,水平角膜曲率为(45.56±2.75) D;而对照组角膜直径为(11.78±0.45) mm,前房深度为(3. 17±0.31) mm,前房容积为(198.74±30. 93) mm^3,前房角度数为(40.05±5.58)°,眼轴长度为(23.77±0.85)mm,下方视网膜神经纤维层厚度为(139. 40±28. 52)μm,水平角膜曲率为(44. 04±1.37) D。AACG组与对照组相比,角膜直径、前房深度、前房容积、前房角度数、眼轴长度和下方视网膜神经纤维层厚度数值的降低差异均有统计学意义(均为P <0.05);而水平角膜曲率和散光度数有明显升高(P<0.05)。进一步通过分析各危险因素在AACG诊断中的权重发现,前房深度、前房容积和前房角度数在AACG的早期诊断中有着较高的权重(分别为2. 85、2. 90和2.62)。结论AACG患者眼部解剖结构均较小。与眼轴长度相比,前房相关参数在AACG的早期诊断中具有更重要的意义。Objective To provide a reliable basis for early screening and intervention of AACG patients,by studying the risk factors associated with the acute angle-closure glaucoma(AACG).Methods A retrospective study of AACG patients’parameters(61 eyes)from June 2013 to July 2015 in Department of Ophthalmology,Zhongshan City People’s Hospital.Control group participants were volunteers without ocular diseases or systematic diseases.Corneal and anterior chamber parameters were measured with Pentacam,axial length and corneal diameter were detected by IOL Master,and retinal nervous fiber layer(RNFL)thickness in four quadrants were gauged by optical coherence tomography(OCT)on binoculus of control group participants and eyes without symptom in AACG patients.And then the relationship between risk factors and AACG prevalence were studied and analyzed.Results In AACG group,anterior chamber depth(ACD)was(1.88±0.43)mm,anterior chamber volume(ACV)was(75.34±36.49)mm 3,angle degree was(25.26±7.67)degree,axial length was(22.16±1.03)mm,inferior RNFL was(118.38±34.78)μm,and horizontal curvature was(45.56±2.75)D;while in control group,ACD was(3.17±0.31)mm,ACV was(198.74±30.93)mm 3,angle degree was(40.05±5.58)degree,axial length was(23.77±0.85)mm,inferior RNFL was(139.40±28.52)μm,and horizontal curvature was(44.04±1.37)D.Compared with the control group,corneal diameter,ACD,ACV,angle degree,axial length and inferior RNFL were significantly statistically less,shallower,lower,narrower,shorter and thinner in AACG patients(all P<0.05);while corneal horizontal curvature and astigmatism degree were significantly lower than those of AACG(P<0.05).Furthermore,the results of anterior chamber depth,anterior chamber volume and angel degree were more important in the host analysis of AACG prevalence than other risk factors(2.85,2.90 and 2.62,respectively).Conclusion AACG patients have a smaller ocular anatomy structure.Anterior chamber-related parameters are more important in the early diagnosis of AACG than axial length.

关 键 词：急性闭角型青光眼 危险因素 眼轴长度 前房角度数 

分 类 号：R775[医药卫生—眼科]