小剂量氯氮平撤药症状的观察  

A survey on withdrawal symptoms of low-dose clozapine

作　　者：刁俊荣 焦琨 张栋 DIAO Jun-rong;JIAO Kun;ZHANG Dong(Linyi Rongjun Hospital,Linyi 276005,China;Linyi Children's Welfare Institute,Linyi 276000,China)

机构地区：[1]临沂市荣军医院,山东临沂276000 [2]临沂市儿童福利院,山东临沂276000

出　　处：《泰山医学院学报》2018年第11期1251-1253,共3页Journal of Taishan Medical College

摘　　要：目的了解小剂量氯氮平的撤药症状。方法对33例长期服用小剂量氯氮平的精神分裂症患者缓慢停药并继续观察2周,分别于停药前后予简明精神病评定量表(BPRS)及副反应量表(TESS)评定疗效及不良反应。结果停药后BPRS总分明显高于撤药前,TESS的行为毒性因子分明显高于撤药前。撤药期间7例(21%)患者睡眠障碍突出,4例(12%)患者精神症状恶化。结论小剂量氯氮平缓慢停用后仍有可能出现较严重撤药症状。Objective:To investigate withdrawal symptoms of low-dose clozapine.Methods:Thirty-three inpatients with schizophrenia who had been treated with low-dose clozapine had clozapine withdrawn slowly,then observed them for two weeks.The brief psychiatric rating scales(BPRS)and treatment emergent symptoms scales(TESS)were used to measure symptoms and side effects before and after withdrawal.Results:The scores of BPRS and behavioral toxicity increased significantly.Sleep disorders of 7 inpatients occurred and mental symptoms of 4 inpatients deteriorated after drug was stopped.Conclusion:It is suggested that the obvious withdrawal symptoms may still occur after slow withdrawal of low-dose clozapine.

关 键 词：小剂量 氯氮平 缓慢停药 撤药症状 

分 类 号：R749[医药卫生—神经病学与精神病学]