中西医结合治疗小儿癫痫强直-阵挛性发作临床价值分析  

Clinical Value of Integrated Traditional Chinese and Western Medicine in Treatment of Ankylosing Clonic Seizures in Children with Epilepsy

作　　者：朱志红[1] 唐基忠 ZHU Zhihong;TANG Jizhong(Anfu County People’s Hospital,Anfu 343200,China)

机构地区：[1]江西省安福县人民医院,江西安福343200

出　　处：《中国医学创新》2018年第30期57-60,共4页Medical Innovation of China

基　　金：江西省卫生计生委中医药科研课题(2017A218)

摘　　要：目的:探讨中西医结合治疗小儿癫痫强直-阵挛性发作临床价值分析。方法:选取2013年1月-2017年1月本院收治的癫痫强直-阵挛性发作患儿100例。按照随机数字表法分为中西组和常规组,各50例。常规组给予丙戊酸钠治疗,中西组在此基础上给予推拿、针灸等中医疗法,比较两组疗效、治疗前后的癫痫发作频率、持续时间、白细胞介素-1β(IL-1β)、胰岛素样生长因子-1(IGF-1)。结果:中西组治疗总有效率为94.00%,高于常规组的76.00%(P<0.05);治疗后,两组癫痫发作频率及持续时间均低于治疗前,且中西组均低于常规组,比较差异均有统计学意义(P<0.05);治疗后,两组IL-1β均低于治疗前,IGF-1均高于治疗前,且中西组IL-1β低于常规组,IGF-1高于常规组,比较差异均有统计学意义(P<0.05)。结论:中西医结合治疗可有效改善癫痫强直-阵挛性发作患儿发作频率及持续时间,有利于提高治疗疗效,且其机制可能与改善IL-1β、IGF-1水平有关,值得临床做进一步推广。Objective:To discuss the clinical value of integrated traditional Chinese and western medicine in treatment of ankylosing clonic seizures in children with epilepsy.Method:A total of 100 epilepsy patients with ankylosing clonic seizures from January 2013 to January 2017 in our hospital were selected.According to the random number table method,they were divided into Chinese and western group and routine group,50 cases in each group.The routine group was treated with Valproate,while Chinese and western group were given massage,acupuncture and other Chinese medicine therapies on the basis of routine group.The efficacy,seizure frequency,duration,interleukin-1β(IL-1β)and insulin-like growth factor-1(IGF-1)before and after treatment between two groups were compared.Result:The total effective rate in Chinese and western group was 94.00%,which was higher than 76.00%in routine group(P<0.05).After treatment,the frequency and duration of seizures in two groups were lower than those of before treatment,and Chinese and western group were lower than those of routine group,the differences were statistically significant(P<0.05).After treatment,the IL-1βlevels in two groups were lower than those of before treatment,the IGF-1 levels were higher than those of before treatment,and the IL-1βlevels in Chinese and western group were lower than those of routine group,the IGF-1 levels were higher than those of routine group,the differences were statistically significant(P<0.05).Conclusion:Integrative Chinese and western medicine treatment can effectively improve the frequency and duration of seizures in children with ankylosing clonic seizures,is conducive to improving the therapeutic effect,and its mechanism may be related to the improvement of IL-1β,IGF-1 levels,it is worthy of further clinical promotion.

关 键 词：中西医结合 小儿 癫痫 强直-阵挛性发作 疗效 

分 类 号：R742.1[医药卫生—神经病学与精神病学]