直接离子化装置研究新进展  

Advances in Ambient Ionization for Mass Spectrometry

作　　者：张兴磊[1] 张华[2] 王新晨 黄科科[2] 王丹[1] 陈焕文[1] ZHANG Xing-Lei;ZHANG Hua;WANG Xin-Chen;HUANG Ke-Ke;WANG Dan;CHEN Huan-Wen(East China University of Technology, Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation,Nanchang 330013,China;State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry,Jilin University,Changchun 130012,China)

机构地区：[1]东华理工大学,江西省质谱科学与仪器重点实验室,南昌330013 [2]吉林大学,无机合成与制备化学国家重点实验室,长春130012

出　　处：《分析化学》2018年第11期1703-1713,共11页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(Nos.21727812,21675021);江西省科技计划项目(No.2010BNB00900);江西省质谱科学与仪器重点实验室开放基金项目(No.JXMS201612)资助。

摘　　要：在常压下直接离子化是质谱分析研究的热点方向之一。经过多年的发展,基于直接离子化而发展起来的复杂基体直接质谱分析技术已广泛应用于各研究领域,日益显示出其重要作用。目前已报道了上百种不同的直接离子化技术,已有不少文献对其进行了总结、分类与展望。本文从能量作用方式的角度,展示典型技术的直接电离工作原理与模式,对近五年出现的新型离子化技术和装置进行总结和简要述评,讨论了现有技术的优缺点,对未来直接离子化技术可能的应用与发展方向进行了展望。Over the past decade,ambient mass spectrometry(AMS)has become an important scientific research tool and is widely used in various important fields such as pharmaceuticals,food,environment,public safety,clinic diagnosis and so on.Ambient ionization technology,as the key for AMS analysis,allows the direct sampling/ionization of analytes from raw practical samples without any sample pretreatment,and has greatly improved the analytical efficiency.At present,nearly 100 kinds of different ambient ionization technologies have been developed for the study of complex solid,gaseous,liquid,and even viscous samples.Herein,the ambient ionization methods were introduced by the aspect of energy and charge transfer process,and the new ambient ionization devices developed in the last 5 years were briefly summarized and discussed.Furthermore,the advantages and disadvantages of ambient ionization technology,and the possible development direction of atmospheric ionization technology in the future were prospected.

关 键 词：质谱 直接离子化 直接分析 能荷传递 评述 

分 类 号：O657.63[理学—分析化学]